Amazing! The 2009 Lincoln & Joyce paper you cited catalyzes one bond per hour on average. (Doubling time = 1 hour, but only one bond between oligonucleotides needed to double.)
OP's Gianni et al 2026 paper connects 45 nucleotides, taking 72 days (1700 hours) to yield 0.2%.
The latter effort is like drawing the whole owl.
That is incredible patience. Without access to the full article, I read only the abstract. I wonder if they used simulations to narrow the candidates?
I learned Perl after trying C; and after struggling with `scanf` (not even getting to tokenization), the ease and speed of `while (<>) { @A = split;` for text-handling made it easy to fall in love. This (in the mid 90s, before Java, JavaScript, and C++ TR1) was also my first contact with associative arrays.
I was also drawn to the style of the Camel Book.
More than most other languages, Perl encouraged one-liners. When I later read PG's "Succinctness is power" essay, I thought of Perl.
which for 2019 describes "0.5 accidents per million departures" and "40 fatalities per trillion revenue passenger kilometers". Considering that many or most passengers fly close to 800-1000 km/h, we're still quite a bit above above 1 fatality per 100 million passenger hours.
Would a factor of 10 be enough? Suppose we go from one major accident per fortnight to one per five months (10 fortnights). Is that higher than what we have seen in the past thirty years?
Not a lawyer, but liability waivers may not apply if there is determined to be gross negligence or recklessness.
Making a reasonably-designed API available, only if connected to an inaccessible network, doesn't sound dangerous, but the goodwill gained might be hard to weigh against a miniscule chance of malware, which would revise everyone's opinion of the degree of negligence or recklessness.
OP's Gianni et al 2026 paper connects 45 nucleotides, taking 72 days (1700 hours) to yield 0.2%.
The latter effort is like drawing the whole owl.
That is incredible patience. Without access to the full article, I read only the abstract. I wonder if they used simulations to narrow the candidates?