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zelse
·20일 전·discuss
We have very few effective antifungals, and discovering new ones is an order of magnitude harder than discovering new antibiotics due to fungi being more closely related to animals (what's toxic to them is often toxic to us). Resistance is an ongoing problem and will worsen in time; Sporothrix already has strains that are resistant to mainline treatment. I recall reading that at least one developing fungal pathogen of concern is in practice impossible to clear from the body fully once established with existing antifungals.

A further issue still is that some fungi exhibit extreme resistance to sterilization; one of the nosocomial emerging fungal pathogens of concern, for example, can easily survive the peroxide fogging technique often used to clean high-risk hospital rooms even at several times the standard exposure duration and concentrations.

Additional issues include treatment compliance - clearing fungal infections can require taking the drug for months without missing a dose.

We should be very concerned about emerging pathogens in light of anthropogenic climate change, but with proper funding and attention this is not necessarily apocalyptic.
zelse
·10개월 전·discuss
In practice, 100%. In theory we could likely design "good enough" anonymous systems that work like buying alcohol or tobacco in most countries (buy a scratch token in cash at a corner store after showing ID, picked at random from a box of them - contains a number, possession of which is theoretical proof that you had your ID verified at purchase)...but of course, the real purpose of age-gating is exerting a chilling effect, so we'll never hear about privacy-preserving methods.

(NB: I am firmly opposed to any of this. The solution for parents concerned about their kids is parenting and parental controls, not giving authoritarians of all stripes the means to snoop and ban whatever they decide is obscene or troubling.)
zelse
·작년·discuss
"They are shrinking from responsibilities such as marriage, homeowning and child-rearing because “adulting is hard”, as one of his students put it. Western culture, Mr Hayward wrote, indulges childish fancies."

Yes, it is surely that young people are just wusses and not that they're also much poorer than previous generations, which forces them to postpone things like marriage, child-rearing, and purchasing a home.
zelse
·작년·discuss
They also have absurdly huge TIFFs of all 3 posters if folks are interested: https://archive.org/search?query=creator%3A%22Gary+Overacre%...
zelse
·작년·discuss
FWIW, your Enterprise key for Win10 should also work to install Win11 enterprise (the MAK keys for the two versions are identical, even), so you can test this fairly easily if you're inclined. That said, I can aver that domain-joining in Win11 doesn't require an MS account - corporations would flip out if that requirement was extended to them.
zelse
·작년·discuss
When I'm carded in RL, it is atypical for my ID to be stored, and I must be informed of the fact. A clerk examines the birthday line, and that is that. There is no record. The purchase is de facto anonymous; if I pay in cash, there is no record correlating me with the transaction.

As a gay man, I am profoundly uncomfortable with the idea of one or more private companies having a durable record of the content I look at, for what I would hope are obvious historical reasons. Additionally, age-gate laws will inevitably be used for oppressive purposes - remember, a substantial number of conservatives view ANY mention of the mere existence of LGBT people or families as inherently pornographic, sexual, or obscene, and those people would absolutely seek to have all LGBT content age-gated. Hell, even without such laws we see this in libraries and schools. The harm that would be averted from age verification online is not proportional to the evils it would give rise to, plain and simple.

The only form of age verification I would ever be OK with would be on the same basis as being carded in RL - something like, at a corner store I could buy a tag with an ID number on it that would count as proof of age for as long as I had it, for online purposes. The clerk would verify my age and then give me a tag in a sealed box with a random number, thus preserving my anonymity from both angles: the clerk would not know what number he sold me, and the state would not know who bought the number, only that the retailer averred that I had had my age verified.
zelse
·2년 전·discuss
This. They're following the Orban-Erdogan-Harper (International Democratic Union) playbook - purge the judiciary of independent judges, control the news media, and open culture-war fronts to distract and sap the strength of opposition while riling up your base. The situation in the world's largest democracy is a very dire one.
zelse
·2년 전·discuss
HaveIbeenpwnd says it was just passwords/usernames/emails, so seemingly not. (My company just got an email from them about the breach and I confirmed I'm in there with a quick search on their website.)
zelse
·2년 전·discuss
I do -- I use WinAmp myself, mostly, but xmplay was updated as recently as 2020 so it's still a thing.
zelse
·2년 전·discuss
It might be, though a lot of municipalities also have bylaws that require certain forms of ground cover on lots, either for aesthetic or drainage purposes.
zelse
·2년 전·discuss
Your handling of folks' feedback in this thread is impressively graceful, fwiw.
zelse
·2년 전·discuss
Plenty of monkeys will opportunistically consume things, and some groups like the baboons and mandrills are gleefully omnivorous and have been known to take down small antelopes. Take a look at those canines and wonder not.
zelse
·2년 전·discuss
The 'Project Farm' reviews on Youtube (https://www.youtube.com/@ProjectFarm) really have been eye-opening for me in that regard; sometimes there is still a strong correlation between price and quality but half the time the best quality (not just price to quality ratio -- subjective or otherwise) ends up clustering in decidedly interesting places.
zelse
·2년 전·discuss
It can make sense for a company where you know the printers will be used regularly and heavily and thus will also be subject to a lot of wear and tear, plus the pricing the big players offer can be pretty decent.
zelse
·2년 전·discuss
Jason @ textfiles also did a nice compilation: http://textfiles.com/underconstruction/

There's a delightful irony in the fact that such a page would absolutely have murdered a browser from its era. Nevertheless, these remind me of a different internet and scratch one heck of a nostalgia zone.
zelse
·2년 전·discuss
Oh neat. Do these writings use Hanzi or something else?
zelse
·2년 전·discuss
Re: Publishing in Mandarin, just in case you're curious:

Mandarin, Cantonese, Hakka, Hokkien, Wu, etc are spoken languages (or dialects, or varieties), but the writing system is common to all of them, albeit in two major forms -- Simplified and Traditional. If I write 恭喜发财, a Mandarin speaker will read that aloud as gongxi facai, a Cantonese speaker as gung hei faat coi, and a Hokkien speaker as kiong-hi hoat-chai, though I left off tone markings even though they're important. In that sense, unless something's romanized, written materials are pretty much just written in 'Chinese', and not any particular variety.

Learning Chinese is funny that way: the spoken language has very simple, regular grammar, but then you also need to learn how to read, write, and pronounce ~3,000 characters to read a newspaper, with a well-educated reader in the language typically recognizing between 8 and 15 thousand characters of the 80,000-100,000 or so that have ever existed (including obscure characters, obsolete characters, regional characters, and variant characters).

It's similar to how if you show a Frenchman, an Englishman, a German and a Pole '456', they'll all know the meaning even if the Englishman thinks "four-hundred fifty-six", and the Frenchman thinks quatre cent cinquante-six.
zelse
·2년 전·discuss
It varies by market a lot. In my part of Canada -- for example -- appliances are almost always included with a house or apartment purchase. Similarly, I only recently learned that in large parts of Canada, it's the norm to rent or lease your water-heater either from a third party or from a utility. Out here in BC, that's not really a thing AFAIK.
zelse
·2년 전·discuss
Northridgefix? Tronicsfix? TheCod3r? (Louis Rossmann, of old?)

There's several of them, but it really depends on the value of the device more than the cost. A lot of what Northridgefix repairs is valuable for the data being recovered more than anything, where the value proposition isn't clear. That said, if someone's paid $2000 for a GPU, I can understand their willingness to pay $300 to get someone to painstakingly microsolder some components back on.