"Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration" - Helen Blau, Baxter Laboratory for Stem Cell Biology & the Donald E. and Delia B. Baxter Foundation Professorship
I recently had to select a 401(k) plan for our small startup. For a startup, the _employee_ fees was significantly better on Guideline (0.15 - 0.3%) than Fidelity (0.5% + $100 bookkeeping fee). The _employer_ fees were slightly more expensive with Guideline ($1,778 on Enterprise plan for Guideline vs $1,200 for Fidelity) but offered more features.
Important for founders in the US to know: you can put up to $70k annually into your 401k using profit sharing, which only some 401k plans offer. Your startup does not need to be making a profit to do 401k profit sharing. Employees may also be able to negotiate this!
It was a surprise learning how applicable your statement is when I was selling technology products into consumer packaged goods (CPG) companies. Consumer preference is very hard to change once it is established, and leading CPG companies spend an enormous amount establishing that preference.
Whatever fills the void for people. ie: instead of bowling leagues, people watch TV or play video games. It's arguably a worse product because it doesn't fulfill the socialization or exercise needs of people, but it does fill the same block of time.
Small organizations exist largely because volunteers will them to exist by donating their time. From our elementary school, it's clear the people who have time to volunteer are the stay-at-home parents. The dominance of two-income households eroded the small organizations, which created a market (distributing the costs over many more people) for large organizations to fill the void with a worse but market-serving product.
I majored in Engineering Physics with an EE focus. Our classes were scheduled so we took the dependent math courses a semester before the relevant EE topics (ie: learned Laplace & Fourier transformations before circuit analysis). The EE majors all took the related math & EE courses simultaneously and visibly struggled, with every class we took together having a bimodal grade distribution.
Paraphrasing from an Oakland police officer reflecting on the spike in crime 3 years ago to today: "Flock has been a game changer. The officers who use it are getting results. Criminals will steal a car, drive through a neighborhood and rob someone. Pretty quickly we can look up 'black BMWs driving around this location'. Maybe 10 come back, you figure out which is the likely one, and then can see where it shows up in the next few hours. Then you have officers on patrol in that area look out for it. The criminals get a police car tailing them & they ditch the vehicle. Instead of doing 5 or 6 robberies with a stolen car, they can do 1 or 2. That makes it much less worth it to do the crimes."