I run NixOS within VMWare Fusion (Mitchell Hashimoto has posted something similar https://github.com/mitchellh/nixos-config) in my M4 Max MBP. It runs pretty well but may hit the battery life sometimes. There are some weird stuff that happens with their GPU accelaration and random Fusion crashes sometimes. I patched Hyprland locally in my config due to a weird (but documented) issue with their GPU accelaration implementation https://github.com/AndrewBastin/nixos-config/blob/main/modul...
I have tested Fusion, Parallels and UTM and Fusion seemed to be the most stable for me.
Really hope the Steam Frame starts shipping at some point. https://store.steampowered.com/hardware/steamframe