It's remarkable how much this still rings true today.
The idea that we should try and understand life as a battle against the second law of thermodynamics has had a significant influence on many of today's great thinkers - such as Friston [1] and Dennett [2], as well as countless others.
I previously tried to sign up via a Google account but it required a 'company Google account' - I was slightly confused about the reasoning behind this.
I used Notion for a significant period but ended up switching to Nuclino [1] - which is identical in many respects, but without the various add-ons that are unnecessary if you're working with text/images.
I've found it to be more responsive, and to my tastes, it has a better UI. I'm not a big fan of the emoji/blank file image that is necessary with every Notion entry.
I mean it's difficult to 'observe' gradient descent, there are no characteristic properties that you can identify without specifying the relative objective function. But most of the process theories from computational neuroscience are based on some form of gradient descent. Even if it's only implicit, you'll be able to describe the variables of the system as moving against the gradient of some function.
But yes, it's extremely unlikely that nature implements backpropagation directly, as it relies on non-local gradients.
As a general answer, the theory suggests that organisms maximize a quantity known as model evidence, which is just a way of saying 'how much evidence does some data provide for my model of the world?'
There are two complementary ways to maximize this - change your model or change your world.
If we now grant that actions also maximize model evidence, then actions can either be conducted to sample data that make the model a better fit of the data (exploration), or they can be conducted to sample observations that are consistent with the current model (exploitation).
I think you might be right, a quote from Friston on the relationship (in reference to belief propagation):
"We turn to the equivalent message passing for continuous variables, which transpires to be predictive coding [...]"
It could be that belief propagation is in the context of discrete variables, whereas predictive coding is in the context of continuous, both of which are a form of (variational) message passing.
It's worth noting that 'free energy' is just the 'evidence lower bound' that is optimized by a large portion of today's machine learning algorithms (i.e. variational auto-encoders).
It's also worth noting that 'predictive coding' - a dominant paradigm in neuroscience - is a form of free energy minimization.
Moreover, free energy minimization (as predictive coding) approximates the backpropagation algorithm [1], but in a biologically plausible fashion. In fact, most biologically plausible deep learning approaches use some form of prediction error signal, and are therefore functionally akin to predictive coding.
Which is all just to say that the notion of free energy minimization is somewhat commonplace in both neuroscience and machine learning.
In terms of the free energy 'principle', it makes no predictions about how free energy minimized. But there have been multiple process theories suggested, most notably predictive coding (which is a dominant paradigm in neuroscience) [1] and variational message passing [2].
Well, a significant portion of empirical neuroscience works under the assumption that parts of the brain operate according to a predictive coding scheme, and there are countless studies that support this notion.
As predictive coding is a form of free energy minimization (under Gaussian assumptions), this implicitly provides empirical evidence.
As for the request to test the idea on live neurons, "In vitro neural networks minimise variational free energy" [1]
There is a large overlap, for instance, the popular VIME exploration algorithm [1] uses part of the free energy objective function.
However, free energy isn't a theory of curiosity per se, its posed as description of self-organisation. It just so happens that you can express the free energy functional in terms of epistemic (curious) and instrumental (reward) components.
The 'revolutionary' aspect is the suggestion that a single celled organism is also doing variational inference. Or, more accurately, can be described as such.
The idea that we should try and understand life as a battle against the second law of thermodynamics has had a significant influence on many of today's great thinkers - such as Friston [1] and Dennett [2], as well as countless others.
[1] https://royalsocietypublishing.org/doi/full/10.1098/rsif.201...
[2] https://www.youtube.com/watch?v=iJ1YxR8qNpY