She comes back to it at the very end pf the series, with a likely explanation of why the special SGB features weren't used:
Now, imagine you’re a Game Boy developer. You want to add the bullet point “Super Game Boy compatible!" to your box, because it’ll help sell a few more copies. But not many people own one. If you want to do something really neat, it’ll add entire days to the project, require changing some art resources, and doing extra testing on a completely different system. Going that extra distance is going to cost a lot of money, and won’t help that much because most people don’t own an SGB to see it. What are you going to say?
I remember hearing in the commentary for The Incredibles that they basically used one basic face model as the basis for everything. I imagine they did this to avoid having to rig individual models for animation every time they made a new one, plus they could do random faces for the minor characters.