itchyouch · HackerTrans

22 godziny temudiscuss

I think you hit on a point with git and sql I made in a different context.

Removing friction from the context and flow. For what git and sql do, they arguably have the most efficient and effective work flows for their purposes.

Managing complexity becomes unavoidable for certain problems, so for challenges of the tool, sometimes, it's simple the challenge of the problem.

I would say his point is not articulated well. Tools should be less toilsome and provide faster feedback loops.

itchyouch

23 godziny temudiscuss

I think of "invisibility" as a way of removing unnecessary friction and the author doesn't quite drive home that point effectively.

Good invisibility is like well designed roads. Smooth, clear markings, adequately wide or narrow for the desired speed, easy and obvious signs. Unbothersome and pleasant. Drivers simply drive, rather than get bothered by, "gotta avoid the pothole. Here's comes the bumpy part. That blindspot, I gotta slow down for way too much. Unseen pedestrians pop out here."

This is where invisibility in interstate highway regulations are obvious.

When I see TUI vs GUI comparisons, it distills to friction for a given context/workflow.

I worked in a restaurant with a micros system. It was a very easy to use GUI that was touch screen button driven. A 1 person order could easily be entered in 6-7 button pushes in 2-3 seconds to a seasoned operator: drink > coke > dish > steak > medium > a1 > submit

The beauty with micros was that it reduced the typical navigate > select > add > back-to-navigate workflow into 1-2 button presses with a receipt-like tally providing immediate state feedback.

In this scenario, telling a user to get into a terminal console and type "cd Foo; ./add ketchup" would violate the invisibility principle. It has nothing to do with TUI or GUI.

To me, good tools get out of the way, in the given context. Micros did that.

CLI users are in a CLI flow, thus introducing a mouse to a keyboard workflow violates the invisibility workflow. But for a GUI user to hit up the terminal violates their flow.

Ultimately, all workflows are in search of a faster/less-toilsome feedback loop to the desired goal and tools are in service to the loop. Well designed tools with rabid followings understand through usage where to add friction, and where to cut toil and I'd argue this is where CLIs shine with decades of refinement of the same tool chain.

GUIs are a, it depends on how composable or self contained the given problem for a GUI interface is.

But yes, tools should be invisible. How they become invisible depends.

itchyouch

2 miesiące temudiscuss

What’s interesting to me is that the conversational nature of the LLM tends to lead folks down an unproductive convo path.

“Don’t do X” is just as useful as telling an infant not to cry.

When an infant cries, we implicitly understand there is a form of discomfort to address (food, diaper, etc).

To me, when a LLM fails, it signals to me that the architecture and structure of the code is problematic and that needs to be addressed.

Any seasoned dev can usually see non-DRY, non-KISS patterns, then will structure an encapsulation around said pattern to address issues.

I’ve found that this same type of refactoring is needed in LLM code to improve its outcomes, of which then it’s capable of overcoming the bugs.

Simply telling the LLM to refactor for cleanliness in between code generation runs will do so much for maintainability.

itchyouch

2 miesiące temudiscuss

I had a very similar reaction.

I went the same way with simply bumping up my bash skills.

Part of me feels like I'd prefer pry loaded with a library that provides shell like methods for doing ruby-esque things.

itchyouch

6 miesięcy temudiscuss

The trick with the vo2 max measurement on the apple watch though is that the person can not waste any time during their outdoor walk and needs to maintain a brisk pace.

Then there's confounders like altitude, elevation gain that can sully the numbers.

It can be pretty great, but it needs a bit of control in order to get a proper reading.

itchyouch

6 miesięcy temudiscuss

When considering NAC's mechanisms, it seems that it's efficacy is likely dependent on an individuals's glutathione status.

I doubt that folks with a solid diet, high in sulfur would find much benefit from NAC.

However, as someone who's gotten to use it first hand and have dealt with lifelong, mild inflammation (puffy fingers, clogged nose here and there), it's definitely been a huge quality of life enhancer.

itchyouch

7 miesięcy temudiscuss

While I can't speak to whether there are enzymes for the proper copy/paste I do have a set of random cancer related bits I've picked up over the years.

There are some basic, well-known nutritional interventions that are generally important/critical for DNA repair processes. The 2 main ones are Vitamin D and Magnesium. Ensuring adequate amount of these tend to be helpful (most folks aren't getting enough sun and greens).

Other than that, a steady and adequate source of the substrates seems to be important: ie protein (nitrogen), and phosphates.

One of the interesting bits about some cancer cells is that while they simply haven't gone through apoptosis, physical sheer stress incurred from physical activity (exercise) can cause cancer cells that travel beyond the tumor point (before it becomes metastatic) to finally self destruct.

It seems important to me that the best strategy for cancer is the compounding of many different strategies that optimize the body's innate defenses to run optimally.

It does seem that ketogenic diets may have adjuvant properties, but there is yet to be a clinical trial that demonstrates it, so it's basically stuck in paper and R&D stages as to whether being in a ketogenic state can be one of the last areas that may help cancer patients extend lifetime from say 1 year to 2 years.

itchyouch

7 miesięcy temudiscuss

I generally agree. It's all interconnected, and we could point to a singular cause, but to treat them all as one and of the same class of disease seems reductive and not useful.

Though, to be play devil's advocate for a second, it does seem that diabetes is typically where the symptoms start, and we do understand that diabetes is fundamentally metabolic and/or functional dysfunction in 1 or more of 7-ish different areas.

I think it's the level of perspective zoom + timing we take that makes the article's assertion either useful or not.

If we zoom out, while catching disease early on, and we address the metabolic conditions via lifestyle and/or certain drugs like GLP1, then we prevent the need to intervene on the kidney and cardiac front.

But if we zoom in to a specific issue, after disease has progressed a profound amount, a GLP1 intervention may be too little, too late.

Hopefully though, this may help the messaging to folks that if they are contending with metabolic disease that presents as diabetes, introducing lifestyle and pharma interventions early may be helpful on the larger epidemiological front.

itchyouch

8 miesięcy temudiscuss

While the area under the curve for glp1 administration may be the same, good chance that the story is informing us of a mechanism such as the absorption rate between two different sites.

Slower absorption in the thigh may blunt the immediate peak dosing and the acute hunger effects.

As always, the small details matter. I'd guess that pharmacology also has their own thundering herd problem with the dosing of certain drugs.

One of the interesting bits about pharmacology seems to not be the active molecule as much as the innovations in delivery mechanism.

itchyouch

8 miesięcy temudiscuss

There were no recommendations.

Usually this type of anecdata becomes the basis of legitimate, controlled studies and over time can inform and/or adjust.

It would be premature to simply write off all influencers or limiting to only accept the medical profession as the immutable truth.

The reality tends to exist somewhere in the middle, outside of a formal proof.

I've listened to many health influencers and among the legitimate and balanced tend to be Rhonda Patrick and Peter Attia.

Attia provides guidelines for how to think about items, but usually it's the fan base that tends to sully the messaging as the base tends to be far more polarized and dogmatic over bits.

It is interesting to see that there is another poster confirming a slightly different effect though. Regardless of things being "systemic", just understanding that fluids dynamics are complex, I imagine diffusion of a systemic molecule like GLp1 could possibly be variable? Or perhaps there is a localized tissue fatigue?

Many potential options do exist to propose as hypothesis.

itchyouch

8 miesięcy temudiscuss

An interesting FYI is a comment made by Peter Attia on his podcast.

He had a patient with metabolic markers that were not improving and they had exhausted all the typical avenues. Presumably they were things like weight loss.

They put the patient on GLP-1 but injected into the thighs (or butt, I don't recall) for the metabolic benefits without the hunger blunting effects.

It seems like GLP1, even in skinny patients (implied by Attia in this particular case), has metabolic benefits.

The longevity community seems to be hinting that there may be geroprotective aspects of GLp1 as well, so we may be looking at the benefits beyond weight loss for metabolism.

itchyouch

9 miesięcy temudiscuss

I've noticed similar satiation with psyllium as well.

I do a 32hr fast once a week and will consume a scoop of psyllium when I get hungry and it's quite filling for 2-3 hours before the hunger kicks back in.

itchyouch

9 miesięcy temudiscuss

As an East Asian, not really trying to argue that China hasn’t accomplished great things.

While I can’t speak directly to this, but from watching The China Show on YouTube, the tradeoff to the amazing amenities is that the personal-injury risk from failing infrastructure has been fatal, but covered up by their propaganda. Anyone on the receiving end of it, will deal with devastating consequences, if not fatal.

Infrastructure and manufacturing corners are cut in ways that look great, but literally kill their population and tourists.

Building foundations are not thick enough, buildings aren’t built to proper fire safety standards, underground pipes leak, leading to roads constantly failing, high rises burn down, sewage pipes literally blow up due to methane build up like someone detonated a bomb.

Drainage grates are fake and flooding cities, drowning people in vehicles, while the QA of car battery manufacturing is causing electric fleets of cars in parking lots to burn.

And the aforementioned occurrences are happening in tier1 cities.

I sound hyperbolic, but China is great at quickly cleaning up and quickly rebuilding, so it doesn’t seem nearly as bad as it does.

Once I learned about the infrastructure, I realized my cousin’s business trip accident in China was not a randomly rare accident.

He broke his back in China when his rental car’s front wheel popped off the car.

Chances are most folks are fine if they go. But I would be very weary, because the probability of a disaster is not nearly as high as it ought to be.

itchyouch

9 miesięcy temudiscuss

It’s likely not a willpower issue as much as the fact that we tend to make choices according to the path of least resistance.

Seems to help to create systems that let us fall to the level of compliance we desire.

itchyouch

3 lata temudiscuss

Funny story. When my friend started playing minesweeper, I would go to his computer and clear out all of his scores by editing in my scores as "beating" him.

Being super competitive, in order not to lose to me, he became a fiend at minesweeper, being able to do solve the beginner series in under 20 seconds. As he would get better and better, I would continue to beat his high score until he had the beginner down to somewhere around 7 seconds.

I changed it to 6 seconds.

He beat it to 5 seconds.

I changed it to 4 seconds.

At that point he was like, WHAT IS GOING ON? And then I showed him how I could just edit the scores. Boy was he dissapointed. But it goes to show how far we can push ourselves if we know that it's "possible."

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