And if you do a dictionary search for "You Guys" you get:
"used in speech and informal writing to refer to or address two or more people"[1]
which seems to imply that it is a gender neutral phrase, despite what the definition for "guys" is. Words can have wildly different definitions depending on the context in which they are used.
[1]https://www.merriam-webster.com/dictionary/you%20guys