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mylons

1,524 karmajoined 15 lat temu
you can find me at mrlyons at gmail

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mylons
·4 dni temu·discuss
haha. hubris thy name is tzumby.

look up what isaac asimov had to say about genomic analysis.
mylons
·w zeszłym miesiącu·discuss
the entitlement people have towards free, open source software, is incredible.

this isn’t even a “new” problem. if you were around in the early 00s or before you probably worked with a BOfH sys admin that didn’t let you update system packages. that person cared deeply about system integrity and enforced it with policies around package managers.

having outsourced all of that stuff over the years to the cloud, it seems like people forgot this reality existed and can still exist.

the mob freak out is really a projection of a skill issue and it’s sad.
mylons
·w zeszłym miesiącu·discuss
what a fascinating take. i just scrolled the github thread. there’s very little, if any substance.

your perception must be very interesting to have gleaned anything but seething AI rage.
mylons
·2 miesiące temu·discuss
github hasn't absorbed agentic coding, though. agentic coding has absorbed it, and as a result it's quality is suffering.

the thing about github that is so maddening is linus gave us the secret with git itself. then we reinvented centralized source control using git and called it github, and here we are.
mylons
·6 miesięcy temu·discuss
my father made reading The Agony and The Ecstasy a requirement to go to Italy when I was a sophomore in high school. It's a thick tome, but a great read if you're a curious kid.

as the others said Michelangelo hated doing that painting. He's a very tragic, albeit heroic to me, man. I'd recommend that book if you're at all fascinated by him.
mylons
·7 miesięcy temu·discuss
last.fm was so promising when it came out but i have to say i didn’t discover anything using their platform.

chatGPT is incredible, just giving it a single song and some context, it can recommend at a rate of something like 85-90%.

the only place i’ve gotten the BEST music recommendations were the oink and last.fm forums. humans, still, are the best recommendation infrastructure.
mylons
·8 miesięcy temu·discuss
i love you guys.
mylons
·8 miesięcy temu·discuss
haha — this is the exact comment i was hoping to see! indeed, i was joking. The Watchmen graphic novel is very important to me as it opened my eyes to the concept of “who watches the watchmen” which I was ultimately eluding to here, albeit extremely facetiously.
mylons
·8 miesięcy temu·discuss
This is GOLD Jerry, Gold.

but who detects the down detector detecting the down detector detecting the down detector
mylons
·8 miesięcy temu·discuss
iran did this to themselves. any other view is simply insane.
mylons
·9 miesięcy temu·discuss
they’ll easily make this up at the parks at the new tron ares ride
mylons
·9 miesięcy temu·discuss
[flagged]
mylons
·9 miesięcy temu·discuss
are you dabbling at all in the “no build js” stuff that Rails 8 supports? i did it for that corporate project and their deploy time went from 30 minutes to 5 minutes. it’s also such a headache reliever but removing most of the confusing aspects of the JS ecosystem for me.
mylons
·9 miesięcy temu·discuss
i came back to rails after a very long hiatus to help a company bring a 10+ year old rails project to Rails 8.x.x from Rails 5. It took a bit to get back in the saddle, but every new project I’ve started since that’s a SaaS/CRUD app of some kind it’s in Rails.

I’m finally at the age where productivity is infinitely more important than anything else.
mylons
·10 miesięcy temu·discuss
fwiw Heng Li was "the author." He was a postdoc under Durbin's professorship. I was around when bwa was developed and was working in a collaboration with Heng Li (I was working on SOLiD R&D). Any development emails were between Heng and our team, we never spoke with Durbin.

first author on a paper like this indicates the most significant contributions https://academic.oup.com/bioinformatics/article/25/14/1754/2...
mylons
·10 miesięcy temu·discuss
this is also the insight that the bwa developer had, to use the burrows-wheeler transform which is part of bzip2 due to it's compression properties being particularly good for genomic sequences.