I do software verification. In my experience, Z3 is consistently but noticeably better than CVC5 at the kinds of problems we generate, though the two tools are close enough that you definitely want to architect your verification tool to be able to use either one (or both at once, in case you hit a problem which is pathological in one but not the other).
One place where Z3 exposes a superior interface to CVC5 is when you want to do term simplification. CVC5 does not have any real analogue to Z3's simplification tactics (like ctx-solver-simplify), so if you want to take a term and simplify it with respect to a set of assumptions, Z3 is your only choice. I think CVC5 has all the machinery you need to implement that stuff inside of it, but as a user you can't access it.
The place where CVC5 really pulls ahead of Z3 is when you want to produce proofs (eg, to integrate SMT solving into a proof assistant like Lean, HOL, or Rocq). Both tools have support for generating proofs, but CVC5's are noticeably less buggy, to the point that Lean's SMT integration uses CVC5, even though Leo de Moura (Lean's designer) was also the original designer of Z3.
If you have a bound on the size of the largest type in your program, then HM type inference is linear in the size of the program text.
The intuition is that you never need to backtrack, so boolean formulae (ie, SAT) offer no help in expressing the type inference problem. That is, if you think of HM as generating a set of constraints, then what HM type inference is doing is producing a conjunction of equality constraints which you then solve using the unification algorithm.
One place where Z3 exposes a superior interface to CVC5 is when you want to do term simplification. CVC5 does not have any real analogue to Z3's simplification tactics (like ctx-solver-simplify), so if you want to take a term and simplify it with respect to a set of assumptions, Z3 is your only choice. I think CVC5 has all the machinery you need to implement that stuff inside of it, but as a user you can't access it.
The place where CVC5 really pulls ahead of Z3 is when you want to produce proofs (eg, to integrate SMT solving into a proof assistant like Lean, HOL, or Rocq). Both tools have support for generating proofs, but CVC5's are noticeably less buggy, to the point that Lean's SMT integration uses CVC5, even though Leo de Moura (Lean's designer) was also the original designer of Z3.