To be clear for other skimmers like me, the "helper" who got 45k is donating to various addresses, not the 600m hacker. (Posting this because I misinterpreted, not because parent was wrong)
I've got no experience with Datasette, but if it's all in pure python, then you can use Pyodide[0] to run it within a wasm module. I was surprised how easy it was - took about 15 minutes and I had a Python package working perfectly in the browser. The Python package is about 3x faster than the JS/wasm version, but I'm guessing that performance gap will narrow when we get wasm-gc.
I get that some people are concerned about github strengthening its monopoly here, but that shouldn't be solved by preventing or opposing the improvement of the platform. There's a sense in which it's like opposing Tesla improving its autopilot tech because it further entrenches them as the leader in the electric car market - or whatever - you get the idea. Monopolies can lead to very bad outcomes for society, but we probably need to handle that by some means other than attacking improvements to the platform.
This comment of course assumes that you think that it is actually an improvement. It does seem like there is a risk of hurting the "spirit" of open source, but then you'd have to hold the position that things like librepay/opencollective/patreon are bad for open source, which at least makes the claim a little dubious. I don't have strong predictions here, but if I had to gamble I'd say that lowing the friction to rewarding content producers (of any sort) is going to be a good think more often than not.