sdbrown · HackerTrans

5 miesięcy temudiscuss

On a related-different axis, I've consistently seen on-prem GPUs running identical workloads ~35% faster than the same workloads on the same cloud hardware, regardless of intermediate infra stack layering/versioning choices. Weird but I'm not complaining!

sdbrown

2 lata temudiscuss

Wasn't this part of the base thesis of "We Have Never Been Modern"?

sdbrown

2 lata temudiscuss

Are you referring to Bruno Latour or the author of the post? If you're referring to Latour, I would strongly urge you to read "Laboratory Life", which is [as] clear and easy to read today as it was when I first encountered it nearly 20 years ago.

sdbrown

3 lata temudiscuss

I don't see dilution anywhere on that page, and increasing volume of administration at a lower concentration to achieve the same effective dose does not alter the dose itself. You are not interpreting TI correctly.

Edit: further, to your comment about "prescription strength" nomenclature, look at section 14 of the Cialis/tadalafil prescribing information, IIRC, table of clinical studies, where they have the second two outcomes of the clinical studies broken down by dose. Efficacy increases pretty directly with increasing dose, and these are where the observed side effects show up. It seems like patients may well self-escalate. Maybe the OTC countries have public data on this?

sdbrown

3 lata temudiscuss

That doesn't change the difference between effective and toxic doses, it changes the potential scale of off-by-one user error. If 20 milligrams is delivered in 1 tablet, then 3 tablets is the toxic dose. If 20 milligrams is delivered in 5 tablets, then 15 is the toxic dose. A single daily tablet is far superior to multiple daily tablets in terms of patient adherence and hence disease management.

Can you name specific examples where the number of pills/capsules/tablets has been increased to improve drug safety? Increased pill counts historically reduces patient adherence, which worses disease management. This is just the first example I found which measured it: https://pubmed.ncbi.nlm.nih.gov/31298592/ This review explicitly states it in the abstract even: https://pubmed.ncbi.nlm.nih.gov/30561486/

sdbrown

3 lata temudiscuss

Tadalafil (Cialis) is available as a generic in the United States. If you think "big pharma" is served by drugs going off-patent, you may want to re-evaluate your perspective.

If you want to get more reasonably unhappy with market exclusivity, look at Celgene's grip on thalidomide/lenalidomide/pomalidomide for the treatment of multiple myeloma.

sdbrown

3 lata temudiscuss

How, in your view, does dilution change the therapeutic index of a chemical? If a drug is effective at 20 milligrams, but at 60 milligrams has a steep rise in the incidence of hypotension, how does taking that same 60 milligrams in a larger volume of filler (e.g. water, or spread across more physical pills) change the fact that you've just taken 60 milligrams?

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