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biophysboy

1,902 karmajoined há 8 anos

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biophysboy
·ontem·discuss
Isn't it just a different form of private capital designed for the later stage of a tech company? I'm not saying its good, but I am not remotely surprised by tech's transition from growth/disruption/hiring to cost-cutting/M&A.
biophysboy
·há 8 dias·discuss
Do you remember some of the studies this book cites? I always thought the drug development lag times and success rate made patents necessary. Do the authors make exceptions for rare disease or CNS therapies?
biophysboy
·há 12 dias·discuss
Give me a break - tech is not remotely interested in comprehensive “systems” thinking about the problems that motivated these age verification policies
biophysboy
·há 15 dias·discuss
I agree with this (I want to be a parent very soon). I think I'm trying to articulate that while its possible to make a quiet place for your kid at home, they still live in a very internet-driven world.

I actually am curious about your experience on this. Basically, I'm worried that I'll try to make restrictions in the future, and it'll just be a war of attrition that I lose, since internet platforms touch so many parts of social life, especially for the young. Maybe things will be different in a decade.
biophysboy
·há 15 dias·discuss
In my opinion, none, but many parents disagree. Also, its more about the secondary effects, where all of their friends at school are talking about internet things they are unfamiliar with.
biophysboy
·há 15 dias·discuss
Its a tragedy of the commons situation. The benefits of being offline are dampened by the kid being out of the loop
biophysboy
·há 23 dias·discuss
Bell labs and IBM made gobs of money in their respective hey days
biophysboy
·há 23 dias·discuss
Yes exactly. It’s like advertising a car by saying “it uses gasoline!” Obviously gas helps the car go, but the user of the car just wants to go places cheaply and reliably
biophysboy
·há 24 dias·discuss
Thats very interesting to me that Watterson remembers his childhood as a difficult time. Calvin’s moments of sadness/anxiety/anger are a big part of why I found those comics so relatable and endearing as a kid.
biophysboy
·há 29 dias·discuss
Two things can be true at once: one group cut funding early 2025, and another group added funding later. The former group, DOGE, was less responsible, and the latter group, USDA, is more responsible. I do not know why I have to ignore the former group to be fair to the latter.
biophysboy
·há 29 dias·discuss
The argument is not that cutting funding caused the problem; the argument is that you have to use money to solve the problem.
biophysboy
·mês passado·discuss
I used to order $10 oligos all the time. The extra length is cool, but I was honestly more impressed by the claims on sequence accuracy in the article. Even a single base pair change can affect the genetics and physics of DNA.

I broadly agree with you on the AI hyping. Data quality and quantity is not high enough in my opinion.
biophysboy
·mês passado·discuss
That number is for the United States, not the United States government
biophysboy
·mês passado·discuss
There is evidence that high-frequency, 50% accurate bot traders make most of the money on prediction markets simply due to being able to make bets faster.
biophysboy
·há 2 meses·discuss
Is the 5% rule for total rent per year?
biophysboy
·há 2 meses·discuss
Protein structure is not a rate-limiting step in drug discovery.
biophysboy
·há 2 meses·discuss
The way I put this to myself is that AI gives “correct correct answers and incorrect correct answers”.

They almost always generate logically correct text, but sometimes that text has a set of incorrect implicit assumptions and decisions that may not be valid for the use case.

Generating a correct correct solution requires proper definition of the problem, which is arguably more challenging than creating the solution.
biophysboy
·há 2 meses·discuss
Yes, I hear you on how academia chases metrics. I would argue this phenomena is not worse than Company Z making a boilerplate AI chat tool that is no more useful than the flagship popular products. I think the fairest comparison is comparing the best researchers in academia/industry. I think they accomplish different things because they have different goals/incentives.
biophysboy
·há 2 meses·discuss
Transformers are an applied science: https://patents.google.com/patent/US10740433B2/en

Basic research would be something like optimal control theory, which came well before the transformer design.

I'm not trying to be evasive; I can see how my distinction could be seen as conveniently just outside industry's purview. Put it this way: I think companies, particularly small ones, are incentivized to pursue well-known methods/materials. Innovation modulates and optimizes.
biophysboy
·há 2 meses·discuss
Departments base grad school admissions on grant awards. The article states: grant awards for MIT went down more than 20%, then new MIT grad students went down 20%. The decrease in students has nothing to do with academia being detached from industry.