A significant effect is through opioid receptor activation, as demonstrated by Williams et al. <https://doi.org/10.1038/s41380-019-0503-4> by blocking the receptor with naltrexone, which attenuated the antisuicidality effects.
Hi, I'm Kevin. I'm a generalist senior software engineer and consultant with over a decade of experience with a broad range of technologies, roles, and industries. I graduated magna cum laude with a B.S. in C.S. from Cornell, co-founded Digital Engine Software in 2009, joined early-stage fintech startup Quantpost in 2013, and have been developing and consulting independently since 2016 for a variety of clients, particularly in home health care and construction. Recently I've worked on many backend web sites and services (ASP.NET+MSSQL and MEAN Stack), automation, integration, and synchronization (Selenium+C#, Python, PowerShell), and Linux DevOps (Docker, Ansible, Bash) projects, but I particularly enjoy lower-level embedded and systems programming. I'm a free and open-source software proponent and contributor. I'm looking forward to joining a team doing meaningful work, particularly toward a social good, contributing my expertise, and learning and collaborating with other professionals.
The Huberman Lab episode Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity <https://www.hubermanlab.com/episode/ketamine-benefits-and-ri...> and the referenced journal articles (including the above) have a lot of detail on it.