I use svelte when I have the choice. If there is a need for a server side story then SvelteKit. I’ve used many different design systems for components including Bootstrap, Material, Carbon, Headless…
I use and like FoalTS. It is a typescript server framework layered over express. It has good documentation, is opinionated about structure and provides a decent CLI for adding controllers, entities, tests, etc. It also includes typeorm for database entity integration. As a bonus OpenAPI support is included to help automate documentation generation for your REST API.