> A group of researchers mostly based at Columbia University are testing whether valacyclovir, an antiviral used against HSV1, can slow down cognitive decline in people with early stage Alzheimer’s. Between 2018 and 2024, the researchers recruited 120 patients and treated half with the antiviral.
Outsider view: while I'm excited we're making progress, I can't shake a feeling of sadness that the best we could manage was a study this small, started 7 years ago. If it's as pivotal as the article suggests, one would hope we could get more than 60 people in the experimental arm (IIUC this antiviral is widely prescribed, well-tolerated, and off-patent). Nonetheless, excited to see the outcome
I have similar issues with sleeping hot. I bought a similar open-knit weighted blanket from yaasa this year and really like it.
Having a small fan blowing air over me also helps quite a bit (the Vornado 5303DC has a remote and can adjust in 1% increments which is very nice for adjusting temp a bit during the night).
I share your concerns about the corrupting influence of money (and the importance of this space), but wanted to point out that Anthropic announced two relevant things last week regarding corporate governance:
First, that it has arranged to be controlled by a Long-Term Benefit Trust: "an independent body of five financially disinterested members with an authority to select and remove a portion of our Board that will grow over time (ultimately, a majority of our Board)". (https://www.anthropic.com/index/the-long-term-benefit-trust)
To name two Turing award winners: are you asserting that Geoff Hinton and Yoshua Bengio are pushing the AI risk narrative primarily because they're compromised by financial incentives?
Geoff Hinton /left his job/ at Google because he sees the risks as real, so I think that's a tough case to make.
I've been on and off Omeprazole, which helps immensely but makes me paranoid about long term effects (like a decade+ - I'm in my 30's).
One thing that has helped a ton is Gaviscon Advance imported from the EU, which contains Sodium Alginate. This was recommended to me by a GI specialist at MGH; the sodium alginate floats to the top of the stomach and forms a sort of physical barrier for a few hours to prevent acid from coming up (alongside other antacids like you'd find in tums). For reasons I don't understand almost nothing is marketed in the US containing it.
The tablets like these (https://www.amazon.com/gp/product/B08GCN88WX/) are honestly pretty palatable - I chew them a couple times and then wash down with water, and it avoids some of the gumminess reviewers describe.
I already bought the game from Nintendo, but stumbled on this thread this morning. I'd be willing to play it on an emulator instead of my switch if the performance was better, but some quick skimming online isn't convincing me.
To wit, the consensus opinion on reddit is that BOTW is still a buggy mess on the main switch emulators, Yuzu & Ryujinx, and that people should play the Wii U version via the CEMU emulator instead. If BotW isn't a polished experience many years after release, I'm pessimistic about TotK being a good experience so soon after release. You can skim the bug reports on the emulator sites; there's lots of stuttering and invisible walls and all other kinds of jank.
Outsider view: while I'm excited we're making progress, I can't shake a feeling of sadness that the best we could manage was a study this small, started 7 years ago. If it's as pivotal as the article suggests, one would hope we could get more than 60 people in the experimental arm (IIUC this antiviral is widely prescribed, well-tolerated, and off-patent). Nonetheless, excited to see the outcome