I looked briefly at Marimo when building - awesome project. I wasn't sure about building on Pydodide as it's obviously not full Python compatibility. But seeing someone else building a popular project on it helped me make that decision!
Maker here! Runs in an isolated Web Worker using Web Assembly, via Pyodide. Everything runs locally in your browser - no file system or other access. Scheduled run (paid plan) run on AWS lambda.
So, yes, sadly, network requests only work with domains with Access-Control-Allow-Origin: *. I'm looking at adding a backend CORS proxy to fix this.
We also have a Chrome extension with no CORS limitation. The extension lets you right-click Python code snippets on basically any site (Claude, ChatGPT, Deepseek etc.) to run it instantly.