I am self-hosting ArchiveBox through yunohost, for the odd blog article I come across and like.
Not a heavy user per se, but it's doing its thing reliably.
I am running GW2 through Steam Proton on Fedora with a custom install location so I don't have to look through the absolutely obscure (heh, forth expansion pun!) directory structure steam hides its games in. Especially non-native ones.
Even arcdps works w/o issues.
In wine for arcdps to work, a dll-override is needed somewhere in the wine settings in some really weird place.