Here is a good quote from the discussion portion of this review:
<blockquote>
As described in the Koob and Volkow model (2016), most drugs of abuse result in the hyperactivation of the mesocorticolimbic dopaminergic reward pathway in the binge-intoxication stage of addiction. This hyperactivation seems to be present in cannabis addiction but to a lower extent. Acute THC administration elicits striatal DA release in animals (Bloomfield et al. 2016) and THC challenges were shown to increase striatal DA transmission in humans (Stokes et al. 2010; Bossong et al. 2015); although other studies have found no THC-induced increases in striatal DA (Barkus et al. 2011; Urban et al. 2012). Additionally, there are no baseline differences in dopamine D2/D3 receptor availability between cannabis users and healthy controls (Volkow et al. 2014c; van de Giessen et al. 2017), a finding that does not parallel addiction to other drugs of abuse (including cocaine, alcohol, methamphetamine, nicotine, or heroin) which is associated with substantial reductions in D2R availability in the ventral striatum (Wang et al. 1997; Volkow et al. 2001, 2014c, 2017c; Martinez et al. 2012; Albrecht et al. 2013; Tomasi et al. 2015a; Wiers et al. 2016a; Ashok et al. 2017). Nonetheless, as with other drugs of abuse, chronic cannabis use still results in blunted dopamine reactivity to a stimulant challenge (Volkow et al. 2014c; van de Giessen et al. 2017).
</blockquote>
furthermore (CUD = Cannabis Use Disorder):
<blockquote>
Interestingly, chronic cannabis use is associated with a downregulation of CB1R – THC’s target receptor – that is restored after 4 weeks of abstinence in humans (Hirvonen et al. 2012). This pattern of abstinence-induced changes in target receptor density is also seen after abstinence from other drugs of abuse such as heroin, stimulants, and alcohol (in humans and animals) but with some caveats: the changes found are not consistent across brain regions for every drug and abstinence periods are not congruent between studies (Wang et al. 2012; Seip-Cammack et al. 2013; Ashok et al. 2017; Volkow et al. 2017c). Future studies should examine to whether changes in target receptors after abstinence are comparable across brain regions and if they follow the same time course in CUD and other SUD.
</blockquote>
Basically, Cannabis is a little addictive, maybe, and abstinence makes most people somewhat cranky and sleepless for a few days.
Personally, I've been a constant consumer for 25+ years, vape all day and grow my own. Quit a week before leaving for a three week international vacation that I'm almost done with, because I was intrigued by the 4 weeks of abstinence quote above. Not much in the way of sleeplessness or crankiness. Plenty of weird dreams though. Just like all my usual abstaining vacations and visits home, which usually don't last a month. YMMV.
IMHO the real addiction is buying seeds. I think I have enough in my fridge to last me the rest of my life :-(
Here is a good quote from the discussion portion of this review:
<blockquote> As described in the Koob and Volkow model (2016), most drugs of abuse result in the hyperactivation of the mesocorticolimbic dopaminergic reward pathway in the binge-intoxication stage of addiction. This hyperactivation seems to be present in cannabis addiction but to a lower extent. Acute THC administration elicits striatal DA release in animals (Bloomfield et al. 2016) and THC challenges were shown to increase striatal DA transmission in humans (Stokes et al. 2010; Bossong et al. 2015); although other studies have found no THC-induced increases in striatal DA (Barkus et al. 2011; Urban et al. 2012). Additionally, there are no baseline differences in dopamine D2/D3 receptor availability between cannabis users and healthy controls (Volkow et al. 2014c; van de Giessen et al. 2017), a finding that does not parallel addiction to other drugs of abuse (including cocaine, alcohol, methamphetamine, nicotine, or heroin) which is associated with substantial reductions in D2R availability in the ventral striatum (Wang et al. 1997; Volkow et al. 2001, 2014c, 2017c; Martinez et al. 2012; Albrecht et al. 2013; Tomasi et al. 2015a; Wiers et al. 2016a; Ashok et al. 2017). Nonetheless, as with other drugs of abuse, chronic cannabis use still results in blunted dopamine reactivity to a stimulant challenge (Volkow et al. 2014c; van de Giessen et al. 2017). </blockquote>
furthermore (CUD = Cannabis Use Disorder):
<blockquote> Interestingly, chronic cannabis use is associated with a downregulation of CB1R – THC’s target receptor – that is restored after 4 weeks of abstinence in humans (Hirvonen et al. 2012). This pattern of abstinence-induced changes in target receptor density is also seen after abstinence from other drugs of abuse such as heroin, stimulants, and alcohol (in humans and animals) but with some caveats: the changes found are not consistent across brain regions for every drug and abstinence periods are not congruent between studies (Wang et al. 2012; Seip-Cammack et al. 2013; Ashok et al. 2017; Volkow et al. 2017c). Future studies should examine to whether changes in target receptors after abstinence are comparable across brain regions and if they follow the same time course in CUD and other SUD. </blockquote>
Basically, Cannabis is a little addictive, maybe, and abstinence makes most people somewhat cranky and sleepless for a few days.
Personally, I've been a constant consumer for 25+ years, vape all day and grow my own. Quit a week before leaving for a three week international vacation that I'm almost done with, because I was intrigued by the 4 weeks of abstinence quote above. Not much in the way of sleeplessness or crankiness. Plenty of weird dreams though. Just like all my usual abstaining vacations and visits home, which usually don't last a month. YMMV.
IMHO the real addiction is buying seeds. I think I have enough in my fridge to last me the rest of my life :-(