I have a friend who has been saved by this and I have two funny points.
CF makes you not process food correctly so you can eat a ton of food and not gain weight. After taking this medicine he was upset because his body started processing food correctly and he put on a bunch of weight initially.
This really is a life saving cure for most general genetic versions of CF but he also remarked that it’s great they found a cure now because it’s basically a white people disease and the amount of funding it got for a cure was likely going to come under scrutiny.
I work at USPS and rural carriers are paid on evaluated time. While some locations don’t get many packages because Amazon has taken the load off with their own contractors, many offices have to make multiple trips because of the package load which essentially means USPS workers in those rural offices are working for free on those second trips. The package load is a real problem.