anatnom · HackerTrans

2 năm trướcdiscuss

If those users aren't reading the error dialogs anyways, why do the error dialogs need to pander to those users? I wonder if the "make it dumb enough for every user to understand" approach leads to user comprehension plateauing prematurely.

anatnom

2 năm trướcdiscuss

From the paper[0]:

> Four predetermined questions were posed regarding sun exposure: (i) How often do you sunbathe during the summertime? (never, 1−14 times, 15−30 times, >30 times); (ii) Do you sunbathe during the winter, such as on vacation to the mountains? (no, 1−3 days, 4−10 days, >10 days); (iii) Do you use tanning beds? (never, 1−3 times per year, 4−10 times per year, >10 times per year); and (iv) Do you go abroad on vacation to swim and sunbathe? (never, once every 1–2 years, once a year, two or more times per year). The four questions were dichotomized into yes/no in the analysis (i.e. sometimes versus no or never). We created a four-score variable as a measure of sun exposure depending on the number of ‘yes’ responses to the above questions on a scale from 0 (avoid sun exposure: reference) to 4 (greatest sun exposure). Sun exposure habits were categorized into three groups: zero ‘yes’ responses (avoidance of sun exposure; the main study group); ‘yes’ responses to one or two questions (moderate exposure); and ‘yes’ responses to three or four questions (greatest exposure).

Of note, the surveys are of Swedish women and were conducted in Swedish. There could be some translation nuance for the word "sunbathe" which doesn't map well to English, or other cultural differences to explain the "but no one I know actually sunbathes..." thought that I immediately jump to.

[0] https://onlinelibrary.wiley.com/doi/10.1111/joim.12496

anatnom

2 năm trướcdiscuss

Instead, I will assume that the FDA has not reversed a decades-long policy without evidence stronger than a local news station which uses a local weed doctor as their quotable source.

The change in _stated_ FDA policy is a huge shift. This explainable-by-a-simple-mistake news article seems much more likely to me. This article header says "Posted at 5:43 AM, Mar 21, 2024 and last updated 2024-03-21 20:13:30-04". That's a 100% full business day where _no other mainstream media_ picked up the story? Possible, but not likely.

anatnom

2 năm trướcdiscuss

I've been hunting for the related source for this (and similar) article today. I cannot find any FDA press releases[1] which point to any documents like this being released. From a YouTube video from the same source as this article, there is a brief image of a document, which is the August 29, 2023 letter from HHS to the FDA [3-redacted].

Has anyone found a more definitive source that the FDA has recently released a "report" with this content? I wonder if this is just slow news day recap of old information.

[1] https://www.fda.gov/news-events/fda-newsroom/press-announcem... [2] https://www.youtube.com/watch?v=0VULoaz3E7o&t=20s [3-redacted] https://www.hhs.gov/sites/default/files/signed-ash-to-dea-le...

anatnom

2 năm trướcdiscuss

The javadoc tool is useful for creating simple HTML documentation directly from the source code. But you end up choosing between making the documentation comments legible as source code or legible as HTML. If HTML javadoc is important to a project, this often means that HTML-in-java-comments will prevail, which in turn means that the developer experience of working on and maintaining those docs is poor. Eclipse and IntelliJ both do good HTML rendering of these comments in mouseover/etc displays, but it is quite annoying to open a file and then need to hover the mouse over the main type just to make the documentation legible.

anatnom

2 năm trướcdiscuss

Confusingly, that wikipedia page cites the same IBTrACS system that I referred to, and in that page[0] the max intensity is listed at 213 knots. The data shows that the 213 knot speed was seen for measurements across twelve hours on 1958-09-24.

[0] https://ncics.org/ibtracs/index.php?name=v04r00-1958263N1314...

anatnom

2 năm trướcdiscuss

Confusingly, the paper[0] cited by this article seems undecided on this front. Figure 1A of the paper puts Hurricane Patricia (2015) into hypothetical category 7, but the "current and proposed categories" in Table 1 stops at declaring category 6 wind speed > 86 m/s (or 192mph, 167 knots, 309 km/h), and category 7 doesn't make an appearance elsewhere in the paper.

I was really hoping to find an authoritative listing of the strongest storms, but it is missing in both the linked article and the underlying paper. The paper itself uses data from International Best Track Archive for Climate Stewardship, which has a confusing website. As a non-expert, the website's top windspeed[1] category lists the following storms with maximum wind speeds of >167 knots (category 6 in the proposed scheme):

    213kt - 1958 IDA
    194kt - 1958 GRACE, 1959 JOAN, 1959 DINAH, 1961 NANCY, 1964 SALLY
    185kt - 2015 PATRICIA
    184kt - 1961 VIOLET
    180kt - 1955 RUTH
    178kt - 1955 JANET,
    174kt - 1951 MARGE, 1953 NINA, 1956 WANDA, 1957 VIRGINIA, 1957 HESTER, 1957 KIT, 1957 LOLA, 1959 VERA, 1959 CHARLOTTE, 1966 KIT
    170kt - 1964 OPAL, 2013 HAIYAN, 2016 MERANTI, 2020 GONI, 2021 SURIGAE

I don't see any explanation for why there were so many fantastically powerful storms in the 1950s-60s. Perhaps the older data is of dubious quality?

[0] https://www.pnas.org/doi/full/10.1073/pnas.2308901121#t01

[1] https://ncics.org/ibtracs/index.php?name=browse-wind#210

anatnom

2 năm trướcdiscuss

The particular chat.svg file in the linked post is (hopefully) not the way that the data will truly be "redacted". This file feels more like an export from a design mockup, as I cannot imagine SVG being the default output format for interacting with OpenAI models.

But I also have extreme doubts that proper redaction can be done robustly. The design mockup image suggests that this will all be done as a step subsequent to response generation. Given the abundance of "prompt jailbreaks", a determined adversary is going to get around this.

anatnom

2 năm trướcdiscuss

The UK also does "chip and pin" authentication for requests, so the waitstaff are forced to either bring a portable cardreader to you or for you to walk to a terminal and enter a code. I think this is why mobile card readers are so common.

In the US, most credit card transactions are simply "(swipe or chip)". If you have the card, you can use it. Gas stations seem to be the slight exception in America -- they generally require "(swipe or chip) and billing zipcode". This is quite funky and not at all secure against fraud.

anatnom

2 năm trướcdiscuss

I took blinatumomab in 2015 (in my late 20s). It literally saved my life. However, the risks of blinatumomab were seen as much riskier than chemotherapy. Most notably, blinatumomab has a significant risk of triggering a cytokine storm[0], a frequently-fatal immune reaction cascade. When starting a cycle of blinatumomab, the hospital required that I be inpatient for 7 days and they checked my vitals at least once every two hours. (This was _miserable_ for my sleep schedule, which is already a mess when in the hospital.) My regimen was 7 days in the hospital, then 21 days at home constantly connected to the pump, then 7 days of recovery time before starting another cycle.

At the time I took blinatumomab, I had already had unsuccessful treatments with two different chemo regimens. At the hospital system I was at, at least one failed chemo regimen was a pre-requisite for blinatumomab, as it was only indicated for "refractory" or "recurrent" cancers. I assume this is more related to the chance of acute death and (at the time) relative newness of blinatumomab compared to established chemotherapy regimens. (B-cell ALL is sadly very common in children, but this fortunately means that there is a LOT of funding research into the disease.)

After going through 3 one-month cycles of blinatumomab, it was becoming less effective, but I was able to line up a allogenic stem cell transplant which has (knock on a thousand woods) kept me clean for the 8 years since.

[0] https://en.wikipedia.org/wiki/Cytokine_storm

anatnom

3 năm trướcdiscuss

The paper's supplementary materials (available from [0]) include an extended case report, which seems pretty interesting.

> [After doing a gene sequence of the patient, we] identified no structural and sequence variants in genes known to be associated with [systemic lupus erythematosus] or diseases of immune dysregulation. However, we detected a [single allele mutation] of unknown significance in [the patient] and her father who had not yet come to medical attention.

The paper seems to be a deep-dive into exploring whether this single mutation is sufficient to explain the micro-characteristics of lupus and concludes that it does.

Given that this mutation was not documented in any public or intra-institution databases, I would expect that this is NOT an explanation for all cases of lupus. It's possible that, like many other genetic- and developmentally-linked disorders, lupus is a cloud of similar outcomes due to many different aberrations.

The biochemistry in the supplementary materials goes WAY over my limited knowledge, but it appears that the researchers went from "this is a weird DNA sequence" to actually manufacturing and testing the (incorrect) proteins in order to conclude that this patient's case of lupus is due to this single mutation. That seems like absolute wizardry. (But I'm also an outsider extrapolating from the linked article and the supplementary materials of the paper.)

[0] https://www.science.org/doi/10.1126/sciimmunol.adi9575?url_v...

anatnom

3 năm trướcdiscuss

> The Geneva meetings were arranged with the knowledge of the White House as well as that of UK and Chinese government officials, according to a negotiator present, who declined to be named.

So...not actually secret diplomacy? Seems like a non-story with the details provided.

anatnom

3 năm trướcdiscuss

UX suggestion: allow dropping on an already-played piece. If the tile you are dropping comes from the tray, put the already-played piece into the tray. If the tile was in the grid, swap the locations of the pieces.

anatnom

3 năm trướcdiscuss

Check out the "Natural Number Game"[0], which is sort of a practical tutorial but leaves a LOT of things unexplained. I took a few proofs-heavy university classes among the math/cs/philosophy departments so the idea of proving arithmetic from axioms wasn't new, but the NNG still took me an outrageous amount of time (easily 100 hours) and I got nowhere near finishing. Perhaps I just never got things to click into place; I am still profoundly confused about what the 'tactics' truly are.

In my opinion, lean4 is not in any way "for beginners" as you mean it; it is a tool for experts in mathematics.

[0] https://adam.math.hhu.de/#/g/leanprover-community/NNG4

anatnom

3 năm trướcdiscuss

In several organizations, I have been the person who writes high-quality documentation. I enjoy writing (and reading) good technical documentation, so this is a self-appointed responsibility. I agree that people aren't interested in documentation for something they either probably-know or probably-don't-need-to-know, so a vacuous thumbs-up emoji is all I expect when creating documentation.

However, the "you can hand out a link" part is what really grinds my gears. The expectation of my former coworkers that it is <someone else>'s job to find the proper documentation pages for them was quite exasperating. '@anatnom can get you the docs for this' and similar messages is...disheartening. My workflow was always to go to <internal docs page> and search for <relevant term>.

Perhaps there are organizations where the documentation-writers are not also encumbered with being the link genie, but I've not had that experience. I wish I could teach a dev to fish, but instead I have to hand out fish all day.

anatnom

3 năm trướcdiscuss

For more comprehensive history/theory of Varespladib for snakebites, check out "Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes" (2022)[0] by the same Dr. Lewin this article is about. There's some interesting discussion of prior research in pigs where oral Varespladib is lifesaving for much longer time spans than injected antivenom, and a ton of somewhat-comprehensible cited sources.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695340/

anatnom

3 năm trướcdiscuss

At scale distances from the 27m sphere planetarium (as the sun), earth would be a 24 cm sphere at distance of 2.8 km. From looking at a map, this could be a basketball somewhere a few blocks NNE of Times Square. (Pluto, however, would be 114km away. Dunno where that would be. Maybe Allentown, PA?)

anatnom

3 năm trướcdiscuss

The premise of this article is better than its execution. The author even points in the direction of open and honest sharing, saying "others could surely have learned from the mistakes I made". But the only mistake pointed to is "I stopped reviewing his original data". Is that the root cause and only way to prevent these problems? If so, drive the point home more firmly.

anatnom

3 năm trướcdiscuss

Woodward and Bernstein were already investigating (for many months prior to the crash), and Nixon's later coverups (after March 1973) don't seem to be connected to the crash in any way.

Perhaps if the crash hadn't happened, the people/money on board could have ensured McCord (and the other plumbers) would have stayed quiet instead of telling Judge Sirica that it was a White House operation. Without some significant evidence of intent for the passengers, though, this is a pretty soft argument.