The safest I know of are infrared saunas (red bulb/near infrared is best), and breathing exercises, as well as overall good nutrition and emotional healing to support the body's natural detox pathways.
Clinical practices like intravenous chelation (ETDA etc) or supplements like spirulina, ALA, NAC, vitamin C, cilantro etc are popular and seem appealing from the promises made in their marketing, but they are often ineffective at removing the most deeply-stored toxins, and can do more harm than good by moving some toxins around the body to places where they can do more damage.
One of my practitioners, who I see every 2-3 months, specializes in releasing “armor” from the body with a specific massage technique.
I can easily believe that in many cases where someone is considered to be moderately-ASD, that it’s a case of this kind of armoring.
This is not to say there is no physiological or genetic component, but that the trauma and armoring is a significant factor in the expression of the condition.
Meditation has only been a very small part of my practice. I've worked with a whole lot of different practitioners since about 2012. I can't really distil a decade plus of healing work into a comment that skeptical readers will find persuasive, but for those wanting to look into it for themselves, books by Gabor Maté and Bruce Lipton are a good start, and practices like Internal Family Systems, Family Constellations, EFT tapping, biofeedback/neurofeedback and Neuro-Emotional Technique are a worth trying.
In principle, emotional healing techniques are effective if they involve "letting go" of the physiological reaction (i.e., "trigger") that is activated when experiencing (or remembering) a traumatic event. Once the physiological reaction ceases to occur, the emotion is "processed", and is just a benign memory like any other. But that can take a huge amount of work over a long time for some complexes, if they are very, erm, complex, and deeply ingrained.
I've probably gone as far down the rabbit hole researching this topic as any lay person can, after running into some pretty major "not living up to my potential" issues in my 20s (I was assessed as not diagnosable as ADHD or ASD by a psychiatrist, but I still seemed to be affected by at least some of the symptoms related to those conditions).
I've been as willing as anybody to believe theories (long commonplace among alt-med communities) like "it's antibiotics", "it's candida yeast" (or insert any other bacterial/fungus/parasite/virus species you can point to), "it's the effect of vaccines on the microbiome", "it's due to microbial dysbiosis in utero".
And after nearly 20 years of researching/contemplating/experimenting, I just find myself thinking "there's no singular, simple explanation or solution". And really, nor should there be; the body is a highly complex system.
Microbiome matters – but there's plenty of stuff you can do to improve it. Metals (mercury, lead, etc) and other environmental toxins (PFAS and other endocrine disruptors [1]) matter – but they can be detoxified over time via some fairly safe and non-invasive techniques. Inflammation matters a lot – and all kinds of things to do with diet, allergens, microbiome influence that. Genetics matter – but probably less than we presume, once all the other factors are considered and addressed (and it's probably more a case of genetic expression in response to stressors, rather than anything hard-coded/deterministic).
A big perspective-shift for me was finding that emotions and trauma matter a huge amount. This is the least-researched and discussed, both in mainstream and the alt-med circles, but in my own experience, nothing has made a bigger difference to my life outcomes (including physiological symptoms like inflammation) than regularly practicing techniques that identify and release deeply-held emotional complexes.
It can seem like an implausible, fringe theory until you think about it this way: if a person is perpetually traumatised, they can be in a "fight/flight/freeze" state, which takes up much of the body's energy and resources, instead of that being directed to healthy immunity (dealing with harmful microbes and allergens), digestion, metabolism, detoxification, tissue repair/growth etc.
And just to confound things even further, having to deal with an unhealthy microbiome in utero or early life can be a cause of trauma (just as it can be in later life when an infection like Epstein Barr can lead to CFS/ME).
I know this all seems very nebulous and speculative; it's taken me a long time to get my head around, but my takeaway after all this time is that to correct these kinds of conditions, these factors all need to be addressed in parallel: emotions, microbiome, toxicity, diet/nutrition.
I'm quite sure there will be no complete understanding and remedy for conditions like ASD and ADHD that doesn't incorporate all these factors.
This comment from a similar thread over 10 years ago pretty much sums it up:
I just saw Sam Altman speak at YCNYC and I was impressed. I have never actually met him or heard him speak before Monday, but one of his stories really stuck out and went something like this:
"We were trying to get a big client for weeks, and they said no and went with a competitor. The competitor already had a terms sheet from the company were we trying to sign up. It was real serious.
We were devastated, but we decided to fly down and sit in their lobby until they would meet with us. So they finally let us talk to them after most of the day.
We then had a few more meetings, and the company wanted to come visit our offices so they could make sure we were a 'real' company. At that time, we were only 5 guys. So we hired a bunch of our college friends to 'work' for us for the day so we could look larger than we actually were. It worked, and we got the contract."
I think the reason why PG respects Sam so much is he is charismatic, resourceful, and just overall seems like a genuine person.
Companies can “fail”, for all kinds of reasons, even with perfect execution by the founders. I don’t really know why Loopt failed, but based on sama’s track record since, he is definitely a person who makes a huge impact with whatever he does (even if you think OpenAI hype is overblown, as I do).
Clinical practices like intravenous chelation (ETDA etc) or supplements like spirulina, ALA, NAC, vitamin C, cilantro etc are popular and seem appealing from the promises made in their marketing, but they are often ineffective at removing the most deeply-stored toxins, and can do more harm than good by moving some toxins around the body to places where they can do more damage.