If she doesn't get it, she's either selfish or you didn't managed to get her to a point where she supports you blindly so you're screwed anyway. So yes, file a divorce for at least one's sake.
* Workout like a horse. Best cure for depression, ever. The feeling I get when running is so liberating that it usually manages to alleviate 99% of the mood problems.
* Sleep like a rock, when you get the chance. Lack of sleep, among alcohol abuse are the most common causes of depression (at least from my personal observation)
* Hang out with friends, family as much as possible, when you get the chance. They'll constantly remind you why you work so hard. Also try to explain them why are you doing certain tradeoffs in your relationship with them.
* Swallow a boatload of Magnesium + B6. IMHO it's the biggest source of happiness one can buy for little money. It keeps your stress levels in control and your heart condition in shape.
* Meditate. I cannot stress this enough. Constantly talk to yourself when you're alone and seek thoroughly for things that cause distress in your life. Debug yourself. You have to like yourself for others to like you!
* Get a girlfriend that understands you or dump the one that doesn't get it (unless you're already married)
After doing a lot of research and attempted to use many wiki systems, we've settled to using Wordpress as our help system. It's got decent search, hierarchical articles that you can easily map into categories, many plugins and so on.
To accomplish this, we've created a custom theme/layout that renders the help categories in a JQuery tree plugin on a left sidebar , search on top and content on the right column.
The effort was about 2-3 days for one frontend developer and the results were quite good, so I highly suggest going this route unless you have other restrictions.