And if the 1 ok-ish candidate study turns out to have significant results, publication bias has to be considered: that dozens or more other studies of vitamin D (or whatever) may have not found significant results of previously ok-ish hypothesis candidates and those negative studies are often not published.
I think this is quite the case for vitamin D which has multiple physiologic roles and is studied extensively for relation to many categories of health issues. One more reason why it can be stunningly impressive when something/anything health-related is eventually proven.
I was gifted an ivory keyed Steinway grand piano in high school by someone who heard me play a couple of simple pieces in a retirement home. I did not know him but a family member was an occasional acquaintance of his. It is a stunning instrument.
I would say software integration is more like a docking mechanism between spacestation units that were designed in isolation by different countries than like snapping LEGO blocks. At least software pieces are products of human design and failure points can be identified without the many inscrutable emergent phenomena and often-unmeasurable unknowns of biology.
I think this is quite the case for vitamin D which has multiple physiologic roles and is studied extensively for relation to many categories of health issues. One more reason why it can be stunningly impressive when something/anything health-related is eventually proven.