michaelhoffman

6 tháng trướcdiscuss

I understand why this is bad, but I personally would sign up for a Microsoft account anyway. Mainly, I don't want all my stuff in "C:\Users\micha". Is there a way to set your username?

michaelhoffman

10 tháng trướcdiscuss

When FASTA was invented in 1985, generally sequencing reads would be about half that.

The simplicity of FASTA seems like a dream compared to the GenBank flat file format used before then. And around the year 2000, less computationally-inclined scientists were storing sequence in Microsoft Word binary .doc files.

A lot of file formats (including bioinformatics formats!) have come and gone in that time period. I don't think many would design it this way today, but it has a lot of nice features like the ones you point out that led to its longevity.

michaelhoffman

năm ngoáidiscuss

Using machine learning, he counted all of the yurts.

Counting all of the yurts that happen to be using machine learning is a way more difficult problem.

michaelhoffman

2 năm trướcdiscuss

> I assume the author means "out of all the ISAs I know"?

Out of all the ISAs where they know whether it provides integer division or not.

michaelhoffman

2 năm trướcdiscuss

This is not "hard-coded" as I would describe it. It is defined in `gv.el`:

    (gv-define-setter buffer-string (store)
  `(insert (prog1 ,store (erase-buffer))))

Unfortunately, it is marked obsolete since 29.1. The NEWS says:

* Many seldom-used generalized variables have been made obsolete. Emacs has a number of rather obscure generalized variables defined, that, for instance, allowed you to say things like:

    (setf (point-min) 4)

These never caught on and have been made obsolete. The form above, for instance, is the same as saying

    (narrow-to-region 4 (point-max))

michaelhoffman

2 năm trướcdiscuss

This used to be the case until Emacs 24.1, in 2012.

    Passing a nil argument to a minor mode function call now ENABLES
    the minor mode unconditionally.  This is so that you can write e.g.
    
        (add-hook 'text-mode-hook #'foo-mode)
    
    to enable foo-mode in Text mode buffers, removing the need for
    'turn-on-foo-mode' style functions.  This affects all mode commands
    defined by 'define-minor-mode'.  If called interactively, the mode
    command still toggles the minor mode.

michaelhoffman

2 năm trướcdiscuss

Wherever possible, I use sina plots, which provide many of the advantages of violin plots while actually showing the individual data points.

https://en.wikipedia.org/wiki/Sina_plot

https://cran.r-project.org/web/packages/sinaplot/vignettes/S...

Adding on a representation of mean in a different style (like a black bar) can be helpful. So can a boxplot-style indication of variance, in some cases.

michaelhoffman

2 năm trướcdiscuss

When would you need to use rdmsr and wrmsr in a crisis?

michaelhoffman

2 năm trướcdiscuss

I wonder if they swapped the benchmark results somehow. Because on my computer, I get roughly the same times but with {} twice as fast as dict().

michaelhoffman

3 năm trướcdiscuss

I don't think so, but in 2023 "PC" can refer to a whole bunch of different things, and "5150" is precisely clear about what it refers to.

michaelhoffman

3 năm trướcdiscuss

I hope it keeps its blazing-fast startup. I regularly used Paint instead of Photoshop on a system where I had both because Paint starts instantly but Photoshop took a bit.

michaelhoffman

3 năm trướcdiscuss

The Bay Area has inadequate public transport for a metro of its size, but its utility is kind of another universe from the Austin's CapMetro.

michaelhoffman

3 năm trướcdiscuss

This is super cool. I use Emacs `abbrev-mode` for taking contemporaneous notes but autosuggesting words would be great.

michaelhoffman

3 năm trướcdiscuss

It seems like you may be reading some things into my comment that I didn't write? I made no claims about the procedure being fair or unfair—I'm just describing what it is.

michaelhoffman

3 năm trướcdiscuss

I am faculty at University of Toronto. As part of the process of considering someone for tenure here, the university solicits six appraisals from relevant experts at other institutions. The candidate will not know who the referees are. Generally, the appraisals are positive; a negative appraisal may severely affect someone's tenure case.

I don't see the concern in this post as one of widespread caste discrimination at University of Toronto, but more that he's worried that a single prejudiced person might upset this, either an external referee, or someone internal involved in the decision-making process. In fact, that is exactly what he says.

https://www.aapm.utoronto.ca/academic-administrative-procedu...

michaelhoffman

3 năm trướcdiscuss

Of course, we don't NEED a new Twitter, but many folks WANT a new Twitter.

michaelhoffman

3 năm trướcdiscuss

They're in good company—the C standard also has something called an "expression statement" which is similar.

michaelhoffman

3 năm trướcdiscuss

> A Python program may contain statements or expressions. Here's a Python program that contains no statements: 42.

According to the Python Language Reference, that is a Python program made of one expression statement:

https://docs.python.org/3/reference/simple_stmts.html#expres...

michaelhoffman

3 năm trướcdiscuss

I like the four-document model. While it isn't a perfect fit for all cases, for many it is a good start.

We wrote a review of bioinformatics software documentation, which includes a taxonomy of research software documentation (Table 1) and examples of which popular bioinformatics software packages use each two (Table 2). It is clear that not every kind is needed for everything, and it's more of a menu than a prescriptive set of documentation types needed for everything:

https://academic.oup.com/bib/article/19/4/693/2907814

michaelhoffman

3 năm trướcdiscuss

How else are they supposed to cross from one corner to the other?

michaelhoffman

Submissions

Anthropic is scraping websites so fast it's causing problems

Okta Mobile Apps Will No Longer Be Available on the China-Based Apple App Store

Understanding metric-related pitfalls in image analysis validation

Methyl-sensitive transcription factor motifs with expanded epigenetic alphabet

Epigenetic misactivation of developmental enhancers drives SOX2 overexpression

Motif elucidation in ChIP-seq datasets with a knockout control

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