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phreeza

9,336 karmajoined 16 năm trước
my email is thomas.mccolgan at g[oogle]mail dot com

i intermittently blog at phonons.wordpress.com

Working on making better proteins with machine learning at cradle.bio

[ my public key: https://keybase.io/tmco; my proof: https://keybase.io/tmco/sigs/P9gtvzmXYJ6NlWm18exm-PIA-JC6RWYr0qUDqxgitSs ]

Submissions

Solar Powered Drone

youtube.com
2 points·by phreeza·8 tháng trước·1 comments

Nipah Binder Protein design competition

proteinbase.com
1 points·by phreeza·9 tháng trước·0 comments

Braincraft challenge – 1000 neurons, 100 seconds, 10 runs, 2 choices, no reward

github.com
83 points·by phreeza·10 tháng trước·3 comments

comments

phreeza
·6 ngày trước·discuss
Or solar geoengineering? Which is scary but becoming more likely it seems.
phreeza
·9 ngày trước·discuss
I think this is a complete misunderstanding of what people mean by taste in software engineering. Taste is more like the System 1 response one builds to code over time, which (ideally) captures the quality of the software beyond surface level, so things like maintainability, composability, readability, likelihood of hidden bugs. This is completely different from the question if the code fulfills the immediate task at hand, but also not the same as pure aesthetics.
phreeza
·21 ngày trước·discuss
Was just going to ask if anyone remembered the name of this one. It was amazing! 15 year old me felt very important/futuristic syncing the news before school in the morning and reading during school break!

Edit: after looking it up with plucker as a starting point I think the one I actually used was AvantGo, same idea though I think.
phreeza
·27 ngày trước·discuss
Maybe its more like the hash was a well known secure hash but someone managed to extract the salt/private key/signing certificate from the camera?
phreeza
·tháng trước·discuss
I ran Claude Code on my ca 2015 ThinkPad which was having wifi issues and asked it to fix them. It diagnosed the problem and applied some obscure kernel flag which fixed the issue.
phreeza
·tháng trước·discuss
There are plenty of expenses in this order of magnitude that are not tied to direct increases in productivity. I think it may become a serious hiring impediment for companies to be really skimpy on these budgets for example.
phreeza
·tháng trước·discuss
Is it really that different with the current iteration of AI compared to what was possible 10 years ago? There may be some new awareness at the executive level of what is possible, but I feel like a "slacker detector" or whatever would have been possible with xgboost or lstms.
phreeza
·tháng trước·discuss
Pretty sure op is talking about university in Spain for other subjects, not Spanish class at university.
phreeza
·2 tháng trước·discuss
I think it's just a joke/reference to HAL in 2001: A Space Odyssey
phreeza
·2 tháng trước·discuss
The most amazing thing to me about Cider-V was that Cider (without the V) actually went away after a relatively short amount of time, when virtually every other internal service that is officially EOL-ed lives on essentially forever.
phreeza
·2 tháng trước·discuss
A rare breed!
phreeza
·2 tháng trước·discuss
That seems possible for generating completely new proteins.

Do you think it's also the case for lead optimization where you typically have some degree of measurements around your starting point, and you are expecting to stay in that local neighborhood for the generated candidates, too?

(Disclaimer: former Cradle employee here)
phreeza
·2 tháng trước·discuss
Check out manifold markets, sounds like that is what you are looking for?
phreeza
·2 tháng trước·discuss
Would you be open to sharing a version of your pitch deck? The main question in my mind is what kind of exit the VCs have in mind when they give you this money.
phreeza
·3 tháng trước·discuss
It seems like college towns have a lot of players even if they are small, what's the reason for that?
phreeza
·3 tháng trước·discuss
That's definitely true for some of them, but for others it's not so clear, like the Apollo or Manhattan projects? Those of course also have lasting impact but it's more in terms of knowledge, which at least arguably we are also accruing with these data centers.
phreeza
·3 tháng trước·discuss
What do you mean you heard? Are you not a member of their team? Your posts in the last hour seem quite astroturf-y.
phreeza
·3 tháng trước·discuss
Numerical issues totally exist but the reason has nothing to do with the fact that Cauchy sequences don't exist on a computer imo.
phreeza
·3 tháng trước·discuss
I understand that much, but it seems like "your naive timestep may need to be smaller than you think or you need to do some extra work" rather than the more fundamental objection from OP?
phreeza
·3 tháng trước·discuss
Doesn't continuous time basically mean "this is what we expect for sufficiently small time steps"? Very similar to how one would for example take the first order Taylor dynamics and use them for "sufficiently small" perturbations from equilibrium. Is there any other magic to continuous time systems that one would not expect to be solved by sufficiently small time steps?