I have used s5cmd in a professional setting and it works wonderfully. I have never attempted to test performance to confirm their claims, but as an out of the box client, it is (anecdotally) significantly faster than anything else I have tried.
My only headache was that I was invoking it from python, and it does not have bindings, so I had to write a custom wrapper to call out to it. I am not sure of the difficulty of adding native support for Python, but I assume its not worth the squeeze and just calling out to a subprocess will work for most user's needs.
I just switched to Tailscale for my home server just before the holidays and it has been absolutely amazing. As someone who knows very little about networking, it was pretty painless to set up. Can’t really speak to the security of the whole system, but I tried my best to follow best practices according to their docs.