“piercing the lumen” is a drastic over-simplification. We don’t know how much LDL is in a healthy lumen (the small amount of research that exists suggests its greater than the serum concentration). Much of it gets there via active transport mechanisms (transcytosis).
Also, why would an endogenously produced protein end up killing you? Seems like evolution run-amok.
Went from codex/claude code -> opencode -> pi -> oh-my-pi