The JackTrip Virtual Studio uses an inexpensive Raspberry Pi, and connects a low latency hardware codec directly into the Pi's bus, to achieve a latency of 1mS. At that level, the only other latency you have to worry about is the speed of light (through the internet). I've just published an article about the Virtual Studio at https://wmleler1.medium.com/setting-up-your-virtual-studio-6...
I've just published an article that goes into depth about how to get a JackTrip Virtual Studio installed. This uses an inexpensive Raspberry Pi instead of requiring installing finicky software on a general purpose laptop or other computer. I wrote this while helping a choir get online, and it worked very well. I hope this helps!
I spent several days with DG when we were working on PIX and QIX, and I found him to be a smart, helpful person. Of course, he was on a crusade for tuple spaces, but you shouldn't hold that against him. Also, that was before he had several fingers blown off.
Another good article to read about this is "Linda Meets Unix", which was published in IEEE Computer magazine. https://ieeexplore.ieee.org/document/44903/ (full disclosure: I wrote it).