passivate · HackerTrans

I don't know if you know this - all rights are made up. To the extent that we can convince others to adopt/agree to them, they can be considered universal, but otherwise they don't mean anything. It remains to be shown, but I would imagine plenty of people would be on-board with having the right to inspect inner workings of things they purchase - including firmware/software as most products have become heavily or completely reliant on software. I think there is a role for commercial proprietary software in our society and so I don't agree with the mission of FSF, but I respect anyone willing to fight for their beliefs.

passivate

4年前讨论

It completely depends on how you approach the term idealism, and what your consider ethical. You're framing the argument as-if goals should be above ones ideals. If you can't convince people about the importance of free-software then the project should die off. I don't see the value in diluting the mission.

Someone who thinks eating sick animals (most meat products) is unethical, isn't going to compromise their personal values just because you're treating them to a meal at the local steakhouse.

passivate

5年前讨论

Why limit it to the US; there is always going to be someone who is worse off than you on the planet. I think its possible to be grateful that you're not that person, but also complain about things that affect you from time to time. :)

passivate

5年前讨论

Yes, there are certain strains that wouldn't work as vectors. HAd26 (used in J&J) has not shown reduced immunogenicity based on studies conducted. It was used in other vaccines previously, and that hasn't impacted its performance here. While it's not a problem now, the situation might change in the future, so you were right to ask the question. These issues of pre-existing immunity are taken seriously inside vaccine companies too.

(Note that while I work in biotech, I'm not claiming to be an expert on this topic, so don't take these as definitive claims of truth. People shouldn't be taking HN comments as a source of any kind of medical advice anyway.)

passivate

5年前讨论

We're not really in disagreement. Let me explain a bit more. Science is a process/methodology of exploring/understanding our natural world/natural phenomenon, Yes? And as such, there is good science, there is average science, and there is junk science. They're all under the same 'Science' umbrella.

>The science that supports the efficacy of vaccination is the data from the trials that shows a reduction in cases. This data is something anyone can understand with sufficient knowledge about probability and statistics.

Yes you have a bunch of numbers, but this doesn't tell you whether the study protocol was good, nor does it tell you about the qualitative aspects like how well the study protocol was adhered to, how tight the controls were, etc. Naturally, this is not a new problem, and we have various safeguards already in place at various levels. You also need a third party like say the FDA to audit and examine what was done.

>This data is something anyone can understand with sufficient knowledge about probability and statistics.

Yes, but that is not all. People need to understand how clinical trials are conducted, and how for e.g. efficacy numbers can't simply be used to trivially compare two vaccine candidates.

passivate

5年前讨论

Because of their confidence (and the FDAs confidence) in their single-dose immunogenicity data, and also the fact that they ran trials in regions (brazil, SA, US) at times when new variants were prevalent.

passivate

5年前讨论

I think it should fall under basic common sense, not science. In reality, only a handful of people in the world understand in detail all the intricacies of the various ways our body interacts with drug substances. This group varies based on the drug in question.

The rest of us are just parroting them. Yes you can try to be informed and read-up but at the end of the day they're still a layperson.

I work in biotech (vaccines), and outside of my little niche, I'm just your average lay person, just slightly more informed.

passivate

5年前讨论

There is the potential for (rare) harmful side-effects from taking many pharmaceuticals. Its all the stuff that they speak at 2x speed after the ad. People (especially the media) are understandably hyper-focused on COVID.

passivate

5年前讨论

This is great news! I'm holding out for the J&J shot myself :) I find it to be a better product than the others.

passivate

5年前讨论

We use Meraki MR/MX stuff at our office and are generally happy with the value & service. The MS stuff though, thats another story. Do you guys have plans to enter the sub $2K tier with L3 devices?

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