Yes. If you ship any eBPF programs that utilize kprobes and/or read kernel structures that change between kernel versions, you have portability problems. See https://facebookmicrosites.github.io/bpf/blog/2020/02/19/bpf... for a good overview of the problem that CO-RE intends to solve.
[1] https://en.wikipedia.org/wiki/U.S._Open_Cup