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epistasis

30,403 karmajoined قبل 16 سنة
Epistasis is one type of evidence of interaction between genes. IMHO these interactions are more important than knowing what the genes are.

Submissions

Constraining U.S. wind and solar deployment could cost an unnecessary $121B

pv-magazine-usa.com
4 points·by epistasis·قبل 19 يومًا·0 comments

Genomic Foundation Models in 2026: What Survives a Held-Out Test Set

rewire.it
1 points·by epistasis·قبل 22 يومًا·0 comments

US battery manufacturing output continues to break records

fred.stlouisfed.org
230 points·by epistasis·قبل 26 يومًا·196 comments

Natural gas share of global electricity mix declines for fifth consecutive year

ember-energy.org
2 points·by epistasis·الشهر الماضي·0 comments

Renewable energy is overtaking traditional power projects across Africa

apnews.com
4 points·by epistasis·الشهر الماضي·0 comments

[untitled]

1 points·by epistasis·قبل شهرين·0 comments

Mozilla says 271 vulnerabilities found by Mythos and "almost no false positives"

arstechnica.com
125 points·by epistasis·قبل شهرين·4 comments

Firm solar and storage costs fall to $54/MWh, says IRENA

pv-magazine.com
38 points·by epistasis·قبل شهرين·0 comments

CATL says sodium batteries are mainstream-ready, signs 60 GWh deal

electrek.co
18 points·by epistasis·قبل شهرين·8 comments

Cheap Batteries Are Taking over the Power Grids

bloomberg.com
15 points·by epistasis·قبل 3 أشهر·1 comments

Elon Musk loses big in court; X boycott perfectly legal

arstechnica.com
22 points·by epistasis·قبل 4 أشهر·0 comments

DOGE goes nuclear: How Trump invited SV into America's nuclear power regulator

propublica.org
18 points·by epistasis·قبل 4 أشهر·2 comments

The US slashed research for cancer, Alzheimer's, mental health – and more

vox.com
81 points·by epistasis·قبل 4 أشهر·2 comments

US added more solar than any other technology in 2025, but is down 14% from 2024

nytimes.com
12 points·by epistasis·قبل 4 أشهر·4 comments

Slow Release of Federal Science Funds Holds Up Research

wnycstudios.org
2 points·by epistasis·قبل 4 أشهر·0 comments

Delays in grant awards and funding calls worry NIH researchers

science.org
3 points·by epistasis·قبل 4 أشهر·0 comments

Google paid startup Form Energy $1B for its 30GWh, 100-hour battery

techcrunch.com
6 points·by epistasis·قبل 4 أشهر·1 comments

TikTok Influencer Accused of Swaying Romanian Presidential Election

bloomberg.com
4 points·by epistasis·قبل 4 أشهر·0 comments

The End of Baseload Power as We Know It

finance.yahoo.com
1 points·by epistasis·قبل 5 أشهر·0 comments

Amazon, Meta, Alphabet report plunging tax bills thanks to AI and tax changes

finance.yahoo.com
45 points·by epistasis·قبل 5 أشهر·47 comments

comments

epistasis
·قبل 14 ساعة·discuss
You are being rude and condescending to a third party, when I think you meant to be rude and condescending to me.

You comment was ambiguous, using pronouns with multiple referents. I chose the referring that was the most charitable possible interpretation of your ambiguous comment. Your intended point is even more obviously wrong.
epistasis
·قبل 3 أيام·discuss
I prefer Pi to Claude Code these days, and use it most of the time when I can. The interaction and permissions harness is an order of magnitude better than Claude in my experience, just out of the box. I barely have time to read all the model output, much less fine tune some crazy agent harness tooling that changes underneath me daily and might or might not be documented.
epistasis
·قبل 3 أيام·discuss
Tariffs are in every way inferior to the prior administration's CHIPS act and IRA, which are in the process of being destroyed merely because they had bipartisan support.
epistasis
·قبل 3 أيام·discuss
I hear this frequently in the US business community, as an alternative to "spending".
epistasis
·قبل 3 أيام·discuss
You were asking if the US was actually preparing to invade Canada, were you not?
epistasis
·قبل 5 أيام·discuss
Did the US make any preparations for war before abducting Maduro from Venezuela or before getting into a war with Iran that cost them freedom of passage in the Strait of Hormuz?

Right up until Russia invaded Ukraine, Russia maintained that, no, that troop buildup wasn't meant as an invasion force, and a good chunk of the world believed Russia because it was a moronic idea to invade Ukraine. Trump is far more moronic and power drunk than Putin, and would perhaps not even organize troops befre invading Canada, all because somebody in the inner circle goaded Trump into it.
epistasis
·قبل 6 أيام·discuss
Eliminating these animations is indeed a massive win.

Overuse of animations is a terrible thing that has made iOS far worse over the years. I long for the days of yore, when the loading screenshot had a chance of being accurate.

These days, when loading something like the health app I get a series of three different screens, rather than just landing at the destination it knew o wanted to start at. It is idiocy of the highest order. Why show some series of random screen transitions while starting the app? Somebody who has no clue about UX programmed that piece of crap, and then an entire team put up with this behavior. I dearsay that if this shipped under jobs there would be a director level firing to stop it.

Same BS happens with Apple Maps. If you launch the app and it remembers that an hour, day, or two weeks ago you had your phone in a particular orientation forever ago, it slowly rotates the view pane over 1000-2000ms from you ancient view pane as if you've been waiting patiently over two weeks so that Maps doesn't suddenly disrupt your view...

Animation can be helpful but at some point a half-wit VP shoved it into everything Ruth disastrous results and Apple is still recovering. Liquid Glass is a similar disaster of incompetence being promoted far beyond capability.
epistasis
·قبل 8 أيام·discuss
How about the one I linked?

Or take any cancer drug approval over the past decades, those all had phase 3 trials that succeeded before the drug was released.

I have to admit that I can even conceive of what your point is here, or why you are acting so emotional and indignant about the required step before drug approval, as if it doesn't exist.
epistasis
·قبل 9 أيام·discuss
That's a tremendous amount of misinformation to pack into a single sentence!

There were several companies working on "old school" style vaccines, they take longer to develop!

And at least one of the old school style vaccines proved to be less safe than the mRNA vaccines and was withdrawn from market, precisely because there were safer vaccines out there so there was no reason to let a less safe version be sold, even though it was still far better than nothing: https://www.science.org/content/article/rare-dangerous-side-...

Further, the very concept of "old school safe tested ones" doesn't even make sense with respect to COVID, because there were no COVID vaccines before COVID existed, and every single vaccine must be tested to evaluate safety.

Further, the concept that "its more difficult to produce inactivated vaccine at mass scale" is at best unsupported for the current day, and back in the early day it was 100% false. Mass producing mRNA vaccines was extremely difficult. They were very quick to design and get a prototype, but mass production was a new and very very difficult effort.

And as for "the reason why they were producing mRNA vaccines" is that the "they" there was a company that focused on mRNA vaccines so of course they would work on that. And the advantage of mRNA is that it is able to be designed and engineered with purpose, rather than the random chance of trying to get an inactivated vaccine, which is far more laborious and slow.

It's so weird to come into these threads on HN and have people just pack so much falsehood into so few characters. Such false information should not be left up uncountered, but it's exhausting to even list what's wrong, much less show all the evidence.
epistasis
·قبل 9 أيام·discuss
https://arstechnica.com/health/2026/06/rfk-jr-stacks-fda-pan...

> As many of us said at the time, the mandates weren't worth the destruction of public trust

Public trust was not dissolved by the actions of the government, it was dissolved by propagandists cynically using falsehoods and half-truths to gain power. That's it.

People don't distrust science because of anything scientists did, it's all because of the propagandists and the easily tricked and the political grifters.

All of your accusations are, in the very best possible light, half truths, but in reality they are just lies. I think the rational part of society is tired of treating liars with kid gloves. The pandemic was a traumatic experience for all, and extra social graces were extended for a while for those who impose upon kind and polite people with their weird beliefs, but we've moved past that moment.

Truth does matter!
epistasis
·قبل 9 أيام·discuss
Of course there's a huge overlap, but perhaps more significantly is that RFK Jr. who is in charge of the entire regulatory structure is both an anti-scientific anti-vaxxer and wants to tear down the safety and efficacy regulations around peptides at the same time:

https://arstechnica.com/health/2026/06/rfk-jr-stacks-fda-pan...
epistasis
·قبل 9 أيام·discuss
The facts are not in your side, but you certainly do have a lot of unfounded FUD.
epistasis
·قبل 9 أيام·discuss
It's quite odd for a person to assert falehoods while also saying "facts matter."

Dec 11 2020- publication of phase 2/3 trial results, meaning not only was the study fully completed, but it made it through peer review too: https://www.nejm.org/doi/full/10.1056/NEJMoa2034577

Dec 11 - 2020: first authorization https://www.nytimes.com/2020/12/11/health/pfizer-vaccine-aut...
epistasis
·قبل 9 أيام·discuss
They confirmed this when the vaccines were authorized. And as part of every drug, there's continual, ongoing, review of the data to ensure that safety is maintained, and that nothing has changed about the drug and its manufacturing. This is the "phase 4" of a drug, continual ongoing monitoring.
epistasis
·قبل 9 أيام·discuss
> Even during the pandemic response it was eventually acknowledged that early claims of vaccines preventing infection or even spread weren't supported by the trials.

To the very best of my knowledge this is just misinformation. If you have a citation here, please provide it.
epistasis
·قبل 9 أيام·discuss
I don't think I'll find that, after investigating the claims I have heard.
epistasis
·قبل 9 أيام·discuss
Yes, I've been very excited about that for more than 10 years. It may not pan out, it's far more speculative than infectious disease prevention, but when combined with checkpoint inhibitors, and I fear they may not do the bold thing and do fully personalized therapeutic vaccines, but it does provide a great deal of hope.
epistasis
·قبل 9 أيام·discuss
[flagged]
epistasis
·قبل 9 أيام·discuss
Which makes sense as they had less access to new technologies, and scaling issues were very hard in the early days.

But I'm not quite sure how that's relevant to the article...
epistasis
·قبل 9 أيام·discuss
[flagged]