Pay attention to the context of that quote about regression to the mean. The problem in this case manifested as the opposite: 'egression from the mean', which can happen due to the combined effects of binning, cross-thresholding and heteroscedasticity (see https://www.biorxiv.org/content/10.1101/2020.12.15.422942v1). I think that _is_ a fairly arcane point, at least to most life scientists.