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haldujai

1,912 karmajoined قبل 13 سنة
haldujai @ google mail provider

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haldujai
·قبل 12 يومًا·discuss
Claude, the model in the post.
haldujai
·قبل 12 يومًا·discuss
Radiologist who does read shoulder MRI would like to add that over half the annotations are wrong, glaring mistakes in anatomy and cardinal direction which begs the question of how is it making these findings without knowing what it’s looking at (here’s a hint, it’s hallucinated based on reports it sees).
haldujai
·قبل 14 يومًا·discuss
Ultrasound is very operator dependent. Shoulder ultrasound is very hard. Visualizing the labrum let alone detecting pathology is very very hard and you will miss huge chunks of it due to limited windows.

Ignoring all of this, there are few sub specialist radiologists in the world who could theoretically do this and if you were to pay for their time it would cost more than a highly reproducible and easy to get MRI.
haldujai
·قبل 14 يومًا·discuss
Half baked images? No one said that is impossible.

I am skeptical of any brain ultrasound claim that doesn’t use skull correction which requires a CT scan.

Very large chunks of vasculature and major arteries are missing in the images they provided. Just because it’s pretty and colorful it doesn’t mean it’s useful.

Perhaps it will one day, but this doesn’t prove much so far. There are several physical challenges to using ultrasound.
haldujai
·قبل 14 يومًا·discuss
Depends for what reason. I trained in Canada. Studies are triaged priority 1 through 4 in most provinces. Nowhere in Canada is a high priority MRI waiting 2 months.
haldujai
·قبل 14 يومًا·discuss
They are mistaken. I am a practicing radiologist in the US. We regularly work-up findings from private pay whole body screening MRIs and the workups are covered by insurance.
haldujai
·قبل 19 يومًا·discuss
It’s called evidence based medicine for a reason. Medicine has long since moved away from making decisions based on whether a person thinks it will be better.

> Ultimately, it should be about personal freedom. This is not a contagious disease we're dealing with here.

The state regulates health and medical devices for a reason. Look at what’s happening with all of these prescription mill apps these days which are still theoretically overseen by a licensed healthcare professional - plenty of medical errors and harm in the name of increasing access (a good thing, when done well). We’ll see criminal investigations within a year.
haldujai
·قبل 21 يومًا·discuss
1. Having concerns over unvetted AI is not the same thing as running an exclusive protectionist racket.

2. Doctors who depend on revenue from forced visits to renew prescriptions are grifters and not close to a majority. The profession obviously isn’t perfect but the vast majority of physicians I know would be happy to lighten their rosters.

With that said it can’t be a system that creates problems and dumps them back on physicians to fix, hence #1
haldujai
·قبل 21 يومًا·discuss
> technically I don't need the doctor

That’s the goal for doctors too. It would be great to get simple things off the system.

But I think the more realistic intermediate step is a trained person cheaper than a doctor - nurse, PA, etc - aided by AI. The current generation of agentic AI doesn’t seem to be there yet and is too agreeable from RL.

“you’re probably fine sleep it off combined with: drink more water, eat healthier, exercise more, sleep better, consume less alcohol and quit smoking/vaping” +/- “we’ll check some labs to make sure” is the correct answer for probably 95%+ of encounters so it’s not hard for an automated system to handle most simple things, even without AI.
haldujai
·قبل 21 يومًا·discuss
My gut as a physician says AI will revolutionize primary care the most and the premise of AI having more specialized knowledge than a PCP holds water - I think the future of primary care is AI equipped midlevel providers - so I was very excited by the intro only to be let down. A lot of buzz about nothing sadly.

The only takeaway here is logging helps detect patterns, we already knew that.
haldujai
·قبل 23 يومًا·discuss
Probably cheaper and substantially better contrast resolution to use low field strength perma magnet MRIs with advanced computation to be honest.
haldujai
·قبل 23 يومًا·discuss
> The brain is encased in bone, so you might get some penetration but it will be very limited.

Radiologist as well. Remember this is full wave inversion not pulsed wave B mode. You can get much more useful information from both high low frequency and capture transmitted waves.

There is promise with this and we use it for example with MRgFUS. With advanced computational models or patient specific CT/ZTE MR aberration correction it is theoretically very feasible to image the brain with ultrasound, whether that’s more useful than say portable low field strength MR is a different question altogether.

> This is cool, but ultrasound is not CT.

Not to be pedantic but since this is a tech forum I would clarify that FWI US is computed tomography by definition (at least in this and many applications). Gas degrades conventional CT too, it’s just worse with US as you have little to no forward propagation and of course innumerable interfaces in the lungs to reflect and scatter.
haldujai
·قبل 23 يومًا·discuss
This is ridiculously optimistic. The technology, USCT with full waveform inversion, is not new.

It’s already used in breast imaging (SoftVue) and hasn’t replace mammography. A body part ideally suited for ultrasound.

More compute many minimize some of the fundamental limits of sound waves (bone and gas) but I would be shocked if they have useful images of 90% of the body parts we image with CT or MRI and even beyond that I question how much it’s more useful than B-mode anyway.

Quite slow which means most things abdomen and chest will be motion degraded.

This may be useful in superficial areas but then why do whole body anyway. Might be some new niches and interesting research but hardly revolutionary in my opinion.
haldujai
·قبل 23 يومًا·discuss
There is some evidence for hormesis - but yes no model is proven right now. LNT is the most conservative model and part of why it sticks around.

A good primer: https://pmc.ncbi.nlm.nih.gov/articles/PMC2477686/
haldujai
·الشهر الماضي·discuss
You’re loosely alluding to personalized medicine but envisioning is a very futuristic state we are very slowly moving towards. What you suggest is great but we are a few decades and several technological breakthroughs as well as new discoveries away from coming to what you are talking.

DNA is increasingly used in oncology, but is difficult to interpret elsewhere and in many tumors is not insightful.

> The data to make the correct diagnosis is out there, we just don't have the tools or processing power to use it yet.

Maybe, but we don’t know what or how to measure it.

> If adrenal nodules of similar diameter behave differently, then the tests will inspect more than just diameter.

Everything investigated so far such as: biopsies with histology, MR spectroscopy and measuring the diffusivity of water molecules has not been reliable in differentiating benign or malignant nodules so we still use size. These are nontrivial problems. There are technical limitations to our measuring tools.
haldujai
·الشهر الماضي·discuss
You’re assuming a diagnostic test can be designed for 100% accuracy and this is not possible as disease states are spectrums not discrete categories.

“Normal ranges” in lab values are just confidence intervals of population means which by definition that some normal people will have abnormal values and some patients with a disease will have normal values.

The same is true for imaging. For example we use size criteria a lot. There is nothing different about 4.1 cm adrenal nodules and 3.9 cm nodules to explain why the former gets surgery and the latter gets called benign other than pre-test probability and acceptable false positive and false negative rates, whether this is measured by a human or AI.
haldujai
·الشهر الماضي·discuss
> There's a term I dislike but is apt: medical misogyny. Basically it's, "systemic, conscious, or unconscious gender biases [which] affect how a patient is treated by the healthcare system."

This is a loaded UK-centric policy/humanities term and I would suggest using sex/gender disparities instead which does not imply animus and is therefore much more useful for productive discussion.

Implicit and systemic biases in medicine are very real and supported by ample data.

> Systemic in particular is that basically the vast amount of knowledge amassed in the medical sciences has come from studying men. Comparatively little for those not assigned male at birth.

At least for the US this hasn’t been the case in clinical research for the past 15 years or so which in aggregate leans a bit more female than male if anything. Some specific fields still have sex disparity in clinical research for a variety of reasons but that’s the minority these days.
haldujai
·الشهر الماضي·discuss
The better question is are there any sources that AI is better than human readers? I haven’t heard anyone make this claim outside of single/few disease classification tasks and even those are mostly 2D.

Anecdotally, my practice has most FDA approved AI deployed as we are an evaluation site and very rarely is the AI result useful. Over the past few months we have been cancelling contracts as these cost quite a lot of money (in some cases eating >50% of the study interpretation cost) for little to no benefit and a LOT of noise.
haldujai
·الشهر الماضي·discuss
Whenever it comes to medical diagnosis I would caution anyone to be careful with what “beat humans” really means.

In real life pathology is a spectrum not a binary and physicians are not trained to be 100% accurate instead optimizing sensitivity and specificity considering pretest probability as well as the harms of overdiagnosis and under diagnosis for a given scenario.

For something like melanoma which is relatively easy to diagnose with a superficial, extremely low risk skin biopsy and where early staging dramatically improves outcomes you would want to design around overcalling (high sensitivity) rather than maximize accuracy given the significant harms with false negatives and minimal harms with false positives.

An AI may be more accurate at classifying melanoma/not melanoma but if it does not meaningfully improve on the clinical threshold of biopsy/no biopsy or result in less biopsies that accuracy is wasted and may even be detrimental.

Note: I am just using this as an example to illustrate the considerations.
haldujai
·الشهر الماضي·discuss
I don’t think so, not beyond the current trend in medicine which is going up anyway.

For some things, like 3D volume segmentation of structure or disease (e.g. CVA/stroke volume, cardiac muscle mass, iron quantification) the bottleneck is the time it takes so we currently use approximations like single longest dimension, circular regions of interest, etc. AI will dramatically increase accuracy allowing for more accurate treatment and easier large scale research with quantitative endpoints.

Other things people think of like detection of aneurysms, fracture, lung nodules are not “hard” but AI has already added and will continue to add the second-reader benefit which will reduce detection errors. For this category the clinical benefit is as of yet unclear and we know that increased detection does not necessarily translate into improved patient outcomes and can in fact make them worse from over-diagnosis which means investigation related harms and over-treatment.

We were already in a phase of “over detection” in much of radiology with advances in imaging technology so the incremental benefit of current AI remains to be seen and I personally think is going to be much more limited. I had a case recently where a 2 mm brain aneurysm was missed on 3 CT scans over 10 years but was picked up by AI so now is being followed annually. This is too small to treat considering the risks and a serious argument could be made that 10 years of stability is proof enough that this is almost certainly clinically irrelevant for this patient.

Far more interesting areas of AI in imaging are in acquisition of acceleration (i.e. the medical equivalent of upscaling) which can dramatically decrease costs and increase accessibility as well as analyzing imperceptible features.

It may not be a popular take here but in my opinion the future of radiology is like what we see in software engineering today - a skilled human equipped with AI will outperform humans without AI and AI without humans, the latter of which we are still several years away from prototyping due to various technical hurdles.