There are libraries such as memflow[0] that let you have DMA to vm using KVM. Though be warned, it's a lot more complicated then injecting a dll or using cheat engine.
On certain minecraft server anti cheats, this used to be a thing. People used to use a hack called "Kill aura" which automatically attacked anyone with a certain distance of you. Minecraft server anti cheats implemented a system which inserted an invisible fake player circling around the player, and if the play consistently hit the fake player they got banned. This system worked pretty well for a while until cheat developers realized they could pretty easily determine the real from the fake anti cheat inserted players.
[0] - https://memflow.github.io/#/home