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noleary

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Pac-832: A New Drug for Alzheimer's Disease

pacepharmaceuticals.com
2 points·by noleary·قبل 14 يومًا·1 comments

Building a custom octocopter from scratch with no prior hardware experience

karolina.mgdubiel.com
418 points·by noleary·قبل 14 يومًا·91 comments

World-first: therapy to make cells young again trialled in a person

nature.com
2 points·by noleary·قبل 24 يومًا·0 comments

Mark Zuckerberg Orders His Employees to Have Fun Again

gadgetreview.com
7 points·by noleary·قبل 24 يومًا·2 comments

Researchers Design and Build First Artificial Protein (2003)

hhmi.org
3 points·by noleary·قبل شهرين·0 comments

Temu is advertising filet mignon on X

twitter.com
58 points·by noleary·قبل شهرين·17 comments

How the Blitz enhanced London's economy

blogs.lse.ac.uk
3 points·by noleary·قبل شهرين·1 comments

Mike: open-source legal AI

mikeoss.com
209 points·by noleary·قبل شهرين·113 comments

Devil worshippers are using AI, exorcists are warned

thetimes.com
5 points·by noleary·قبل 3 أشهر·0 comments

American Exchange Group to buy sneaker maker Allbirds for $39M

reuters.com
2 points·by noleary·قبل 3 أشهر·0 comments

Sycophantic AI decreases prosocial intentions and promotes dependence

science.org
4 points·by noleary·قبل 4 أشهر·1 comments

Building FireStriker: Making Civic Tech Free

firestriker.org
139 points·by noleary·قبل 4 أشهر·27 comments

Ant Chat

baothiento.com
15 points·by noleary·قبل 4 أشهر·7 comments

Tome: Open-source documentation platform with Markdown

github.com
9 points·by noleary·قبل 4 أشهر·1 comments

Spacetime DB: running a live video call over a database

twitter.com
2 points·by noleary·قبل 4 أشهر·0 comments

America has a tungsten problem

noleary.com
205 points·by noleary·قبل 5 أشهر·201 comments

Frog 'saunas' could help endangered species beat a deadly fungus (2024)

science.org
26 points·by noleary·قبل 5 أشهر·4 comments

US Supreme Court to decide if the pesticide Roundup is shielded from lawsuits

nytimes.com
7 points·by noleary·قبل 6 أشهر·0 comments

The industrial waste site that glitters like a glacier

nationalgeographic.com
2 points·by noleary·قبل 6 أشهر·0 comments

Vanderbilt University plans new campus in San Francisco

wsj.com
18 points·by noleary·قبل 6 أشهر·15 comments

comments

noleary
·قبل شهرين·discuss
There've been some interesting new developments in cell therapies over the last few years. Bemdaneprocel from BlueRock Therapeutics is now into Phase 3 trials for Parkinson's, for example. The essential idea is to implant some dopaminergic neuron precursors to grow new cells in place of cell death. Still a long way from the kind of general stroke treatment you're describing, but regenerative neuroscience is looking pretty promising.

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[1] https://www.bluerocktx.com/bluerock-therapeutics-announces-p...
noleary
·قبل 4 أشهر·discuss
Also linking here the creator's broader portfolio: https://www.baothiento.com/
noleary
·قبل 4 أشهر·discuss
Seems to be changing the .org to a .com

https://firestriker.org/blog/building-firestriker-why-im-mak...

--

related, author is a friend with a less active HN account https://news.ycombinator.com/user?id=blakeofwilliam
noleary
·قبل 5 أشهر·discuss
> If you build apps with a lot of traffic, you know the first thing to break is the database.

Just out of curiosity, what kinds of high-traffic apps have been most interested in using PgDog? I see you guys have Coinbase and Ramp logos on your homepage -- seems like fintech is a fit?
noleary
·قبل 5 أشهر·discuss
FYI, Tungsten prices are quoted in metric ton units (MTUs) [1], which surprisingly aren't metric tons. They're actually 1% of a metric ton -- or 10kg. [2] So the price of Tungsten is actually 100x that.

[1] https://www.fastmarkets.com/metals-and-mining/minor-metals/t...

[2] https://quoteddata.com/glossary/mtu/
noleary
·قبل 5 أشهر·discuss
I'm not smart enough to stake an opinion on the viability of fusion. I pretty much only have high school mechanics and Wikipedia in my toolkit.

I can only ever make material conditional claims about things like this :)
noleary
·قبل 5 أشهر·discuss
Hey, I wrote the article. This is my personal website that I wrote mostly over the weekend.

I went down a rabbit hole reading about metals and mining and just thought it was interesting. Not an expert or a nefarious actor, unfortunately.
noleary
·قبل 5 أشهر·discuss
Reserves means something specific in the context of minerals! Reserves measure 'economically viable' deposits. [1]

There used to be tons of tungsten mines in the USA, e.g. in Colorado linked below.

[1] https://resourcecapitalfunds.com/insights/rcf-partners-blog/...

[2] https://coloradogeologicalsurvey.org/publications/tungsten-m...
noleary
·قبل 6 أشهر·discuss
https://archive.md/zqPZA
noleary
·قبل 6 أشهر·discuss
> We responsibly disclosed this vulnerability to Notion via HackerOne. Unfortunately, they said “we're closing this finding as `Not Applicable`”.
noleary
·قبل 6 أشهر·discuss
Related: https://news.ycombinator.com/item?id=46527706
noleary
·قبل 9 أشهر·discuss
It's not that uncommon to keep the "CTO" title and not be the primary manager of the engineering organization. There are all kinds of things you can do with the org chart. If I recall correctly, Clickhouse works this way.

The company's cofounders comprise three people [1]:

* Aaron, a sales-oriented CEO from Elastic and Salesforce

* Alexey, the original Clickhouse developer, as CTO

* Yury, an experienced engineering executive from Google/Netflix as "President"

An excerpt from the launch announcement [2]:

> While negotiations were still ongoing, Katz decided they needed a third co-founder. “I kept thinking, if I could get a third co-founder to run product and engineering, and if I could find someone with the same level of experience building distributed systems on open-source that I have on go-to-market, it could be a really compelling combination,” Katz says.

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[1] https://clickhouse.com/company/our-story

[2] https://www.indexventures.com/perspectives/the-fast-and-the-...
noleary
·قبل 10 أشهر·discuss
Ontario Teachers' is a pretty active principal in venture/growth financings and a major LP to a bunch of funds. That said, venture/growth is a pretty small percentage of their holdings.

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[1] https://www.crunchbase.com/organization/ontario-teachers-pen...

[2] https://www.otpp.com/en-ca/investments/our-investments/teach...