HackerTrans
TopNewTrendsCommentsPastAskShowJobs

yosame

245 karmajoined قبل 5 سنوات

comments

yosame
·أول أمس·discuss
People are more lenient on farming because humans need agriculture to survive. Obviously not all agriculture is necessary for survival, but it's something that in some way provides real tangible benefits for everyone.

On the other hand, if AI data centres all disappeared today, humanity would continue on completely fine.
yosame
·قبل 14 يومًا·discuss
Posting a claude chat is not actually helpful. The chat doesnt't even cite any sources.

I think this post is a decent summary, the answer is a soft maybe: https://www.health.harvard.edu/mind-and-mood/should-i-worry-...

Second-gen tablets might increase dementia risk by a small-to-medium amount (there's almost certainly still a small degree of CNS activity, and we don't know what causes dementia in the first place), but researching it will be difficult. Dementia is hard to research because of how long it takes to develop, and it's poor coding within health data, and antihistamines are hard to research because they're not often prescribed and aren't available in the health data.

If it's a large effect, those factors wouldn't matter, but smaller risks are harder to detect and more sensitive to bias. If you want to minimise dementia risk, then reducing antihistamine use might be warranted, but you're probably better off addressing the risk factors we do know about: https://www.dementia.org.au/brain-health/risk-factors-develo...
yosame
·قبل 3 أشهر·discuss
In my experience with health data, the dates are usually offset by a random but constant amount for each person (e.g. id 12345 will have all their dates shifted by +5 weeks) to avoid identification by dates.

Unfortunately the sequence of treatments and locations are usually enough to identify someone, especially if it's a rarer condition.
yosame
·قبل 3 أشهر·discuss
Not really, you still have to validate the structures it estimates, which minimises any speed gains.

It can help a little bit in the early stages of drug design, but even if it was perfect (which it's not), there's a massive gap between understanding a protein structure, and understanding how a drug will or system will interact with it.

In a broader sense, understanding the structure of a protein is only a small part of drug development. Unfortunately biology is complicated, and we're an extremely far way away from solving it.
yosame
·قبل 4 أشهر·discuss
I mean the difference is that you just take one in the morning? Which makes adherence easier, makes sure that the delay is constant rather than variable, and reduces abuse liability.

(As an aside, there are more complex extended release mechanisms than just delayed bead release - like lisfexamfetamine is a inactive prodrug, so cleaving the lysine off the amphetamine is rate limited. This has the effect of extended the duration of effect, and reduces the potential to abuse by snorting/iv/etc).
yosame
·قبل 7 أشهر·discuss
I'm pretty sure this take is incorrect on multiple accounts. Trans demographics tend to skew towards trans women by about a third, not trans men - at least in all the research I've come across.

And regardless, increased acceptance and awareness of different gender identities can very plausibily explain increased numbers, not "social contagion". Calling it a contagion is pretty indicative of your underlying beliefs here.
yosame
·قبل 8 أشهر·discuss
Hilariously, this is the second Sam that wants to collect everyones iris's for nefarious purposes
yosame
·قبل 8 أشهر·discuss
Why would ChatGPT replace google search when search also has AI? At best they'd steal some of Google's market share, which I'd imagine would decline with embedded ads.
yosame
·قبل 9 أشهر·discuss
Could you share a guide for how you did this? I've got a TCL TV, and it's constantly frustrating how it shows laggy ads.
yosame
·قبل 10 أشهر·discuss
Edibles wouldn't have enough sugar to singularly cause diabetes.
yosame
·قبل 4 سنوات·discuss
Maybe you could run all your communications through a translator twice (e.g. English -> French, French -> English), and fix any typos?

It would hopefully keep the sentiment while changing the words.