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prnewswire.com
1 points·by disco_nap·4 ปีที่แล้ว·0 comments

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disco_nap
·4 ปีที่แล้ว·discuss
The focus on this article is demographics, but the most important things to tribes are our language, culture, and tribal sovereignty. We are not a box on a census form and never will be.

We are pre-Constitutional sovereigns, recognized by our treaties with the U.S. and Canada. States like Michigan might force our teachers get "foreign language certificates," despite the fact that Michigan is a word from our language[0], but my children speak their language and our culture are pillars of strength and stability in our family. Blood quanta, problems of race in America, what to call us -- that's not our focus.

[0]https://www.interlochenpublicradio.org/michigan-education/20...
disco_nap
·5 ปีที่แล้ว·discuss
Are the losses thermal? How significantly could this change the ocean temperature near the cable? 50% of 600 GW is enough to cause a 10C increase in the temperature of 10 million liters of seawater every second?
disco_nap
·5 ปีที่แล้ว·discuss
I think it should be obvious that you cannot study electrical excitability in dead, fixed cadaver tissue.

This is top-notch science, but might be hard for people to appreciate.
disco_nap
·5 ปีที่แล้ว·discuss
This study does not report that that layer V cortical neurons are missing a particular ion channel. They examine currents through HCN and voltaged-gated potassium channels and find differences in the total current carried that depends on species.

In general, epileptic disorders are observed across species. It's common in dogs, for instance: https://www.akcchf.org/canine-health/top-health-concerns/epi...

A ton of papers examining ion channel expression in epilepsy that should be more relevant: https://pubmed.ncbi.nlm.nih.gov/?term=human+ion+channel+epil...
disco_nap
·5 ปีที่แล้ว·discuss
The majority of a neuron's transmembrane capacitance is attributed to the lipid membrane itself, so a lower density of ion channels should not appreciably alter capacitance.

Action potential rates and the ability to phase-lock to inputs are significantly affected by the membrane time constant. Generally, membranes with lower conductances at rest and during spiking will have higher (slower) membrane time constants. This isn't a straightforward explanation for the ability of human some neurons to phase lock to higher frequencies.

Impedance data across species relevant to this idea is in Extended Data Figure 2 and 5 of the paper.
disco_nap
·5 ปีที่แล้ว·discuss
The original research article is the subject of an editorial expression of concern. There is no direct evidence to support the title of the post.
disco_nap
·5 ปีที่แล้ว·discuss
As an academic neuroscientist doing animal experiments, my hope is that animal research will eventually be obsolete, but think we are 1-2 centuries away from the required technology to do mechanistic and ethical experiments in ourselves. The article points out some questionable experiments but left out what we have learned/developed using animal models. This includes sars-cov-2 vaccines [1], the molecular identity of neurotransmitters [2], and gene therapies for SMA1, which typically kills children before their fifth birthday [3]. Animal activist's hearts are in the right place and we try to treat them as ethically as we can. I personally known several patients with ALS who have died and feel incredible urgency as a scientist. Animal testing is currently highly effective and irreplaceable. I would urge people who's perspective on animal testing is shaped by interactions with their pets to volunteer with charities that aid families with seriously ill children [4].

1 https://www.theatlantic.com/science/archive/2020/08/america-...

2 https://journals.physiology.org/doi/pdf/10.1152/classicessay...

3 https://www.nejm.org/doi/full/10.1056/NEJMoa1706198

4 https://www.rmhc.org/