PyScript has actually been massively refactored in the last few months and is much faster now. You can check the performance of PyScript running MicroPython here: https://laffra.github.io/ltk/
If you need/choose Pyodide load time will of course by much more but that's mostly because of the size of full core Python and the dependencies you might have.
If you need/choose Pyodide load time will of course by much more but that's mostly because of the size of full core Python and the dependencies you might have.