himom

8 ปีที่แล้วdiscuss

But first one must be able to connect with people... since I can’t do that, the rest is considered behaviors of an pointless, unrespectable, unworthy fool, while everyone else is mostly “take, take, take.”

himom

8 ปีที่แล้วdiscuss

    #ifndef SUCCESSFUL_H_
    #define SUCCESSFUL_H_ 1
    #ifdef __cplusplus
    extern "C" {
    #endif
    int will_code_for_awesome_benefits(void);
    #ifdef __cplusplus
    }
    #endif
    #endif /* SUCCESSFUL_H_ */

I guess the OP implies there’s a difference between a contractor making say, $45k USD/yr, with an unsteady existence of temporary work and an SA/SWE-SRE/TPM/SRM at Alphabet making $325k/yr in a fairly-cushy, mostly certain job with full-time benefits.

himom

8 ปีที่แล้วdiscuss

No, read the source article.

The validation data are taken at baseline from three previously published studies investigating pharmaceutical interventions to normalize metabolic abnormalities of children with ASD31: (1) a combination of methylcobalamin and low dose folinic acid32, 33 (2) high dose folinic acid,34 and (3) sapropternin.35 Given that these studies all focused on evaluating treatment strategies for ASD, all participants had a confirmed diagnosis of ASD. FOCM/TS metabolites were available for 154 (76% male) participants with ASD with a mean age of 8.8 years (range 2–17 years). These ages are different than reported by Delhey et al.34 because this study only required that measurements be available at baseline, rather than both at baseline as well as the conclusion of the treatment phase. Furthermore, stratifying patients by age or gender did not reveal any differences in the univariate metabolite distributions. The first two studies were approved by the IRB at the University of Arkansas for Medical Sciences and the third study was approved by the IRB at the University of Texas Health Science Center at Houston. All parents gave written, signed consent and patients provided assent when appropriate.

2.3 Metabolites

The metabolites under investigation are presented in Table 1 and additional details of these measurements and derivations are presented in Melnyk, et al.30 This is only a subset of the measurements investigated previously29 because “% DNA methylation” and “8‐OHG” were absent from the validation data set and were therefore removed from this study to ensure that a consistent set of metabolites are used for training and testing.

(Table 1 - 22 metabolic variables considered)

https://onlinelibrary.wiley.com/doi/full/10.1002/btm2.10095

I’m curious if these metabolic abnormalities apply to adults as well. I had an ADOS at the UCD MIND Institute come back with a 7 (1-14 scale IIRC) about 10 years ago.

PS: PKU treatment sapropterin (Kuvan) costs $100k USD/yr

himom

8 ปีที่แล้วdiscuss

Ever since the JDK 1.0 days, I didn’t get why there was this C/C++ carry-over inconsistency of manually-boxed types and non-Objects primitive types separated from Objects. A type hierarchy, patterned similar to Ruby’s as an example, makes the most sense:

- Object contains a Class that it derrives from (no BaseObject or Modules)

- Class is an Object

- String is an Object

- Boolean is a two-value singleton of true and false

- Number is an abstract subclass of Object

- Decimal and Integer are abstract subclasses of Number

- Float, Double, LongDouble, BigDecimal are concrete subclasses of Decimal

- SignedByte, Byte, Short, UnsignedShort, Int, Unsigned, Long, UnsignedLong, Char, BigInt are concrete subclasses of Integer (or U/I/F## types reminiscent of Rust instead of C type names)

and so on.

Then there is no boxing/unboxing of simple types or literals because they are one-and-the-same, and no there’s no confusion about how to interact with any truly generic type of value.

himom

8 ปีที่แล้วdiscuss

It’s called an use tax. It’s equivalent to a sales tax, reporting is required but voluntary. Not paying use taxes on internet purchases is tax evasion. Here’s what CA’s state tax collectors have to say:

https://www.ftb.ca.gov/individuals/use-tax.shtml

https://www.cdtfa.ca.gov/taxes-and-fees/use-tax.htm

himom

8 ปีที่แล้วdiscuss

First, random trade wars, raising prices for all those clueless, provincial consumers whom don’t realize what made Walmart prices cheap. Next, cuts to MedicAid for tax breaks for the very rich that are literally blood money by killing people, throwing them off health insurance and sentencing them to bankruptcy. Then their genius band of self-destructive nincompoops hurls some more arbitrary taxes onto the people whom can least afford it, i.e., anyone not rich. Is this the same, worn political cycle of “sabotage the country while blaming the other side for doing” it gambit as usual? smh

himom

8 ปีที่แล้วdiscuss

It’s absurd how much goes into the bin. Why can’t restaurants especially use cloth napkins that are cleaned off-site and also silverware, plates and cups like what was done for centuries? Getting all restaurants’ service paraphernalia away from disposable-like-Ikea-furniture to nearly zero waste seems entirely doableb because that’s how it was before. Even store beverage containers like seltzer water are refilled without melting them down, why can’t more manufacturers go back to the deposit system and just clean containers instead of completely destroying and remaking them for every use?

himom

8 ปีที่แล้วdiscuss

Stanford / Palo Alto gave up on a lot of recycling and went to “off-site sorting.” Stanford used to have 5! bins.

Another fail is “recycling” at Costco, where basically no recycling happens and people just throw things in carelessly into any of the 3 bins. Worse, the staff contribute to its demise equally by eliminating the sorting signs and turning bins around to hide their labeling. Red, green, blue ... go figure which is which.

himom

8 ปีที่แล้วdiscuss

Future home of The Island of Doctor Moreau or a Four-Assed Monkey (s01e05). Srsly: At some point, a sizable-enough brain develops a degree of consciousness. Are we really going to test the mad scientist hypothesis that your brain might be in a Petri dish somewhere and that your senses are artificial? NM: https://nypost.com/2015/08/19/scientist-creates-99-complete-...

himom

8 ปีที่แล้วdiscuss

Corruption: It’s What’s For Dinner™

himom

8 ปีที่แล้วdiscuss

CB is a YC alum.

himom

8 ปีที่แล้วdiscuss

Yeah, it seems like more and more people are delaying kids until it’s “now or never” scenario. Not good. Have kids as early as possible because of the work and energy involved.

It’s not just fertility that declines, but IQ and a rise in birth defects.

himom

8 ปีที่แล้วdiscuss

US immigration detention centers are now listed as concentration camps. It’s also interesting a number of them privately-owned (ie GEO Group, etc.) and also that many businesses, per article, enable their existence for blood money.

It’s the opposite of virtue-signaling if you live and work for what’s right, not out of what’s most expedient or wins popularity points, but out of integrity. Too few people these days have the courage to think deeply and act consistently regarding the big issues impact of their choices of consumption, associations and work income. (Focusing too much on tiny issues would exclude everyone.)

himom

8 ปีที่แล้วdiscuss

Except for case, bolt already is a puppet project. Not a huge deal since both projects are widely-spaced.

himom

8 ปีที่แล้วdiscuss

Ouch. Sounds like a failed state scenario: anarchy by services disappearing and unconcern for community. When a government ceases to provide a fundamental function, such as protecting its citizens, it risks irrelevancy... and citizens better form their own government to replace the one not doing its job, or they’re inviting criminal thugs reminiscent of ISIS to fill the power-vacuum.

himom

8 ปีที่แล้วdiscuss

It seems like there oughta be an app that can make it easy to pick non-/emergency numbers for a given location, type of service and jurisdiction (highway/state, unincorporated/county sheriff, incorporated/municipality, park ranger, tribal, military, etc.)

himom

8 ปีที่แล้วdiscuss

I realize you can’t necessarily comment on individual deployments, but I’d like to publicly shame Vacaville, CA’s e911 combined with Verizon and/or iPhone plain doesn’t work. Contacting the FCC, Verizon determined they were sending valid position information but the city/county weren’t necessarily using it correctly. All it takes is for a rape/murder to happen and police unable to get to a victim because of it for some heads to roll, but unfortunately, it will take death(s) before such a problem is resolved.

himom

8 ปีที่แล้วdiscuss

Q: America has minor drug users incarcerated for life, and the highest per-capita incarceration rate in the world, save Seychelles. How many Wall St. bankers, corrupt DC lobbyists or public officials are in jail for their crimes? A: very few, just to make an ostensible show of a statement now and then to mollify the people during tough times. The bigger the crime, the lesser the time.

himom

8 ปีที่แล้วdiscuss

Regardless of medical / health insurance purposes, actuaries have been doing this for over a century esp. to price life insurance, among other things.

himom

8 ปีที่แล้วdiscuss

With deep learning, actuaries were inevitably, mostly obsolete, at some point. It’s unpleasant to think, that in a way, tech can now readily disrupt nearly any arbitrary office-worker knowledge industry at will, destroying businesses and specialties and concentrate both capability and wealth in ever fewer hands. Coding isn’t a “forever” specialty either... self-coding machines will create languages, protocols and systems humans will likely be unable to understand, limit, modify, monitor or audit.

Submissions

Bye HN: Existentially-rational, self-termination

Massive AI Twitter probe draws heat map of entrepreneurial personality

There’s a word for elaborately-constructed imaginary worlds

Jerry, the independent inventor whom had 600+ patents, torpedoed big corps

$2B lawsuit claims Apple Watch idea was stolen

Quora 504ing

Gia-Fu Feng: A Contemporary of Jack Kerouac

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