68k: complex, but tidy
x86: complex, and grubby
What worked for x86, though, was the sheer size of the x86 market, which resulted in better compiler support, more tuning effort, and vastly more commercial optimisation work than m68k. But that is not the same claim as «68k was harder to optimise because it was more CISC-y».
You might be thinking SGI who went in big on NUMA. IBM and HP have also built ccNUMA systems (e.g. HP Superdome and Superdome 2).