I had an opiate after surgery once and the constipation was so bad, it was worse than the pain it was supposed to be treating. I switched to Aleve instead, which was both better at pain management and had fewer side effects.
I was thinking about this the other day, and I don’t plan on buying another car until something self-driving is available. Waymo is rolling out to my metro this year (Denver) and I bet I’ll be able to buy a self-driving vehicle within 10 years, which is well within the life of my current vehicle.